Cellosaurus cell line MDCKII-LE (CVCL

Cross-references
Cell line name	MDCKII-LE
Synonyms	MDCKII-Low Efflux; RRCK; Ralph Russ Canine Kidney
Accession	CVCL_VR40
Resource Identification Initiative	To cite this cell line use: MDCKII-LE (RRID:CVCL_VR40)
Comments	Characteristics: Compared to the parent cell line, has a lower expression of endogenous ABCB1/MDR1. Derived from site: In situ; Kidney; UBERON=UBERON_0002113. Cell type: Epithelial cell of kidney; CL=CL_0002518.
Species of origin	Canis lupus familiaris (Dog) (Canis familiaris) (NCBI Taxonomy: 9615) Breed/subspecies: Cocker Spaniel; VBO=VBO_0200372.
Hierarchy	Parent: CVCL_0424 (MDCK-II)
Sex of cell	Female
Age at sampling	Adult
Category	Spontaneously immortalized cell line
Publications	PubMed=21766308; DOI=10.1002/jps.22674 Li Di, Carrie Whitney-Pickett, John P. Umland, Hui Zhang, Xun Zhang, David F. Gebhard, Yu-Rong Lai, James J. Federico 3rd, Ralph E. Davidson, Russ Smith, Eric L. Reyner ...Show all 20 authors... , Caroline Lee, Bo Feng, Charles J. Rotter, Manthena V. Varma, Sarah Kempshall, Katherine Fenner, Ayman F. El-Kattan, Theodore E. Liston, Matthew D. Troutman; Show fewer authors Development of a new permeability assay using low-efflux MDCKII cells. J. Pharm. Sci. 100:4974-4985(2011)
Chemistry resources	ChEMBL-Cells; CHEMBL4295481 ChEMBL-Targets; CHEMBL4296468 PubChem_Cell_line; CVCL_VR40
Encyclopedic resources	Wikidata; Q95987829
Entry history
Entry creation	13-Nov-2018
Last entry update	10-Sep-2024
Version number	8