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Cellosaurus RR-H460 (CVCL_VQ68)

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Cell line name RR-H460
Synonyms Radiation-Resistant-H460
Accession CVCL_VQ68
Resource Identification Initiative To cite this cell line use: RR-H460 (RRID:CVCL_VQ68)
Comments Population: Caucasian.
Characteristics: The parent cell line was irradiated with 20 Gy.
Selected for resistance to: NCIt; C17262; X-Ray.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gln61His (c.183A>T); ClinVar=VCV000045117; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Leu289_Lys292del; Zygosity=Unspecified; Note=Produces a truncated protein (PubMed=24558369).
Disease Lung large cell carcinoma (NCIt: C4450)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0459 (NCI-H460)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=24558369; DOI=10.1371/journal.pone.0087492; PMCID=PMC3928108
Yun-Guang Sun, Carey Jeanne Myers, Adam Paul Dicker, Bo Lu;
A novel radiation-induced p53 mutation is not implicated in radiation resistance via a dominant-negative effect.
PLoS ONE 9:e87492.1-e87492.10(2014)

Cross-references
Cell line databases/resources cancercelllines; CVCL_VQ68
Encyclopedic resources Wikidata; Q98129187
Entry history
Entry creation13-Nov-2018
Last entry update19-Dec-2024
Version number10