ID   RR-H460
AC   CVCL_VQ68
SY   Radiation-Resistant-H460
DR   cancercelllines; CVCL_VQ68
DR   Wikidata; Q98129187
RX   PubMed=24558369;
CC   Population: Caucasian.
CC   Characteristics: The parent cell line was irradiated with 20 Gy.
CC   Selected for resistance to: NCIt; C17262; X-Ray.
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gln61His (c.183A>T); ClinVar=VCV000045117; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Leu289_Lys292del; Zygosity=Unspecified; Note=Produces a truncated protein (PubMed=24558369).
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C4450; Lung large cell carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0459 ! NCI-H460
SX   Male
AG   Age unspecified
CA   Cancer cell line
DT   Created: 13-11-18; Last updated: 05-10-23; Version: 9
//
RX   PubMed=24558369; DOI=10.1371/journal.pone.0087492; PMCID=PMC3928108;
RA   Sun Y.-G., Myers C.J., Dicker A.P., Lu B.;
RT   "A novel radiation-induced p53 mutation is not implicated in radiation
RT   resistance via a dominant-negative effect.";
RL   PLoS ONE 9:E87492-E87492(2014).
//