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Cellosaurus XP129 (CVCL_VP51)

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Cell line name XP129
Accession CVCL_VP51
Resource Identification Initiative To cite this cell line use: XP129 (RRID:CVCL_VP51)
Comments Population: Palestinian.
Characteristics: Revertant in term of the XP12RO phenotype.
Selected for resistance to: NCIt; C17231; Ultraviolet radiation.
Transformant: ChEBI; CHEBI_23994; Ethyl methanesulfonate (Methylsulfonic acid ethyl ester; MSEE).
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Cell type: Fibroblast of skin; CL=CL_0002620.
Sequence variations
  • Mutation; HGNC; HGNC:12814; XPA; Simple; p.Arg207Gly (c.619C>G); Zygosity=Unspecified (PubMed=8464385).
Disease Xeroderma pigmentosum, complementation group A (NCIt: C3965)
Xeroderma pigmentosum (ORDO: Orphanet_910)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_VP50 (XP12RO)
Sex of cell Male
Age at sampling 12Y
Category Transformed cell line
Publications

PubMed=2823132; DOI=10.1016/0167-8817(87)90024-1
Ljiljana Vuksanovic, James Edward Cleaver;
Unique cross-link and monoadduct repair characteristics of a xeroderma pigmentosum revertant cell line.
Mutat. Res. 184:255-263(1987)

PubMed=3118197; DOI=10.1128/mcb.7.9.3353-3357.1987; PMCID=PMC367978
James Edward Cleaver, Felipe Cortes, Louise H. Lutze-Mann, William F. Morgan, Audrey N. Player, David L. Mitchell;
Unique DNA repair properties of a xeroderma pigmentosum revertant.
Mol. Cell. Biol. 7:3353-3357(1987)

PubMed=1549511; DOI=10.1093/nar/20.5.991; PMCID=PMC312081
Christopher J. Jones, James Edward Cleaver, Richard Dean Wood;
Repair of damaged DNA by extracts from a xeroderma pigmentosum complementation group A revertant and expression of a protein absent in its parental cell line.
Nucleic Acids Res. 20:991-995(1992)

PubMed=8464385; DOI=10.1093/mutage/8.2.155
Mindy L. McDowell, Thai Nguyen, James Edward Cleaver;
A single-site mutation in the XPAC gene alters photoproduct recognition.
Mutagenesis 8:155-161(1993)

Cross-references
Encyclopedic resources Wikidata; Q98135268
Entry history
Entry creation07-Sep-2018
Last entry update19-Dec-2024
Version number9