Cellosaurus logo
expasy logo

Cellosaurus OR6 [Human] (CVCL_VN30)

[Text][XML][JSON]
Cell line name OR6 [Human]
Synonyms OR-6
Accession CVCL_VN30
Resource Identification Initiative To cite this cell line use: OR6 [Human] (RRID:CVCL_VN30)
Comments Population: Japanese.
Characteristics: Transfected with ORN/C-5B/KE RNA, a construct containing Renilla reniformis renilla-type luciferase, neo and genome-length HCV RNA from O strain (genotype 1b).
Virology: Supports hepatitis C virus (HCV) replication.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Genetic integration: Method=Transfection; Gene=UniProtKB; P27652; Renilla reniformis renilla-type luciferase.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; HGNC:6307; KDR; Simple; p.Gln472His (c.1416A>T); ClinVar=VCV000134603; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:20932; POLD3; Simple; p.Lys109Arg (c.326A>G) (p.Lys70Arg, c.209A>G); Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr220Cys (c.659A>G); ClinVar=VCV000127819; Zygosity=Homozygous (from parent cell line).
Disease Adult hepatocellular carcinoma (NCIt: C7956)
Adult hepatocellular carcinoma (ORDO: Orphanet_210159)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0336 (Huh-7)
Sex of cell Male
Age at sampling 57Y
Category Cancer cell line
Publications

PubMed=15766575; DOI=10.1016/j.bbrc.2005.02.138
Masanori Ikeda, Ken-ichi Abe, Hiromichi Dansako, Takashi Nakamura, Kazuhito Naka, Nobuyuki Kato;
Efficient replication of a full-length hepatitis C virus genome, strain O, in cell culture, and development of a luciferase reporter system.
Biochem. Biophys. Res. Commun. 329:1350-1359(2005)

PubMed=21320556; DOI=10.1016/j.virusres.2011.02.005
Kyoko Mori, Masanori Ikeda, Yasuo Ariumi, Hiromichi Dansako, Takaji Wakita, Nobuyuki Kato;
Mechanism of action of ribavirin in a novel hepatitis C virus replication cell system.
Virus Res. 157:61-70(2011)

Cross-references
Cell line databases/resources cancercelllines; CVCL_VN30
Anatomy/cell type resources BTO; BTO_0006069
Encyclopedic resources Wikidata; Q98128353
Entry history
Entry creation07-Sep-2018
Last entry update14-Aug-2025
Version number14