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Cellosaurus RUES2 HOPX-tdTomato (CVCL_VM29)

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Cell line name RUES2 HOPX-tdTomato
Synonyms RUES2 HOPX-td-Tomato
Accession CVCL_VM29
Resource Identification Initiative To cite this cell line use: RUES2 HOPX-tdTomato (RRID:CVCL_VM29)
Comments Characteristics: Using CRISPR/Cas9 a tdTomato-pA-loxP-PGKp-PuroR-pA-loxP was integrated at the HOPX translational start site.
Genetic integration: Method=CRISPR/Cas9; Gene=FPbase; PGG5S; tdTomato (Note=Bright red fluorescent protein derived from drFP583 (DsRed)).
Genetic integration: Method=CRISPR/Cas9; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
Derived from site: In situ; Blastocyst; UBERON=UBERON_0000358.
Cell type: Embryonic stem cell; CL=CL_0002322.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_B810 (RUES2)
Sex of cell Female
Age at sampling Blastocyst stage
Category Embryonic stem cell
Publications

PubMed=28813672; DOI=10.1016/j.celrep.2017.07.067; PMCID=PMC5576510
Nathan J. Palpant, Yu-Liang Wang, Brandon Hadland, Rebecca J. Zaunbrecher, Meredith Redd, Daniel Jones, Lil Pabon, Rajan Jain, Jonathan Epstein, Walter Larry Ruzzo, Ying Zheng ...Show all 14 authors... , Irwin David Bernstein, Adam A. Margolin, Charles E. Murry; Show fewer authors
Chromatin and transcriptional analysis of mesoderm progenitor cells Identifies HOPX as a regulator of primitive hematopoiesis.
Cell Rep. 20:1597-1608(2017)

PubMed=30290179; DOI=10.1016/j.stem.2018.09.009; PMCID=PMC6220122
Clayton E. Friedman, Quan Nguyen, Samuel W. Lukowski, Abbigail Helfer, Han Sheng Chiu, Jason Miklas, Shiri Levy, Sheng-Bao Suo, Jing-Dong Jackie Han, Pierre Osteil, Guang-Dun Peng ...Show all 26 authors... , Nai-He Jing, Gregory J. Baillie, Anne Senabouth, Angelika N. Christ, Timothy James Caird Bruxner, Charles E. Murry, Emily S. Wong, Jun Ding, Yu-Liang Wang, James Hudson, Hannele Ruohola-Baker, Ziv Bar-Joseph, Patrick Ping Leu Tam, Joseph E. Powell, Nathan J. Palpant; Show fewer authors
Single-cell transcriptomic analysis of cardiac differentiation from human PSCs reveals HOPX-dependent cardiomyocyte maturation.
Cell Stem Cell 23:586-598.e8(2018)

Cross-references
Encyclopedic resources Wikidata; Q98129218
Entry history
Entry creation07-Sep-2018
Last entry update14-Aug-2025
Version number11