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Cellosaurus UM-UC-3-LuL-2 (CVCL_VL58)

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Cell line name UM-UC-3-LuL-2
Synonyms LuL-2; Luciferase Lung metastasis-2
Accession CVCL_VL58
Resource Identification Initiative To cite this cell line use: UM-UC-3-LuL-2 (RRID:CVCL_VL58)
Comments Population: Caucasian.
Characteristics: Produced after passage of UM-UC-3-LuL-1 into nude mice.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P08659; Photinus pyralis firefly-type luciferase.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
Derived from site: In situ; Urinary bladder; UBERON=UBERON_0001255.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Gene deletion; HGNC; HGNC:9588; PTEN; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:795; ATM; Simple; p.Gln2800fs*6 (c.8400delG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Cys (c.34G>T); ClinVar=VCV000012578; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:14446; PARD3B; Unexplicit; Ex9-18del; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Phe113Cys (c.338T>G); ClinVar=VCV000634690; Zygosity=Homozygous (from parent cell line).
Disease Bladder carcinoma (NCIt: C4912)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_VL57 (UM-UC-3-LuL-1)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=21482678; DOI=10.1158/0008-5472.CAN-11-0519; PMCID=PMC4283788
Jonathan B. Overdevest, Shibu Thomas, Glen Kristiansen, Donna Elizabeth Hansel, Steven Christopher Smith, Dan Theodorescu;
CD24 offers a therapeutic target for control of bladder cancer metastasis based on a requirement for lung colonization.
Cancer Res. 71:3802-3811(2011)

PubMed=29732388; DOI=10.3233/BLC-180167; PMCID=PMC5929350
Tahlita C.M. Zuiverloon, Florus Christiaan de Jong, James C. Costello, Dan Theodorescu;
Systematic review: characteristics and preclinical uses of bladder cancer cell lines.
Bladder Cancer 4:169-183(2018)

Cross-references
Cell line databases/resources cancercelllines; CVCL_VL58
Encyclopedic resources Wikidata; Q98134085
Entry history
Entry creation07-Sep-2018
Last entry update14-Aug-2025
Version number13