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Cellosaurus NCI-H358a (CVCL_VK07)

[Text version]
Cell line name NCI-H358a
Synonyms H358a
Accession CVCL_VK07
Resource Identification Initiative To cite this cell line use: NCI-H358a (RRID:CVCL_VK07)
Comments Population: Caucasian.
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Cell type: Club cell; CL=CL_0000158.
Sequence variations
  • Gene deletion; HGNC; 11998; TP53; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 2514; CTNNB1; Simple; p.Thr75Ala (c.223A>G); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Cys (c.34G>T); ClinVar=VCV000012578; Zygosity=Heterozygous (from parent cell line).
Disease Minimally invasive lung adenocarcinoma (NCIt: C2923)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1559 (NCI-H358)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line

PubMed=8280799; DOI=10.1089/hum.1993.4.5-617
Cai D.-W., Mukhopadhyay T., Liu Y.-J., Fujiwara T., Roth J.A.
Stable expression of the wild-type p53 gene in human lung cancer cells after retrovirus-mediated gene transfer.
Hum. Gene Ther. 4:617-624(1993)

PubMed=8089864; DOI=10.1093/jnci/86.19.1458
Fujiwara T., Cai D.-W., Georges R.N., Mukhopadhyay T., Grimm E.A., Roth J.A.
Therapeutic effect of a retroviral wild-type p53 expression vector in an orthotopic lung cancer model.
J. Natl. Cancer Inst. 86:1458-1462(1994)

Cell line databases/resources cancercelllines; CVCL_VK07
Encyclopedic resources Wikidata; Q95993568
Entry history
Entry creation07-Sep-2018
Last entry update05-Oct-2023
Version number12