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Cellosaurus MWCL-1/IR (CVCL_VJ32)

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Cell line name MWCL-1/IR
Accession CVCL_VJ32
Resource Identification Initiative To cite this cell line use: MWCL-1/IR (RRID:CVCL_VJ32)
Comments Selected for resistance to: ChEBI; CHEBI_76612; Ibrutinib (Imbruvica).
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Mutation; HGNC; HGNC:7562; MYD88; Simple; p.Leu252Pro (c.755T>C) (p.Leu265Pro, c.794T>C) (L265P); ClinVar=VCV000037055; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Val143Ala (c.428T>C); ClinVar=VCV000804214; Zygosity=Hemizygous (from parent cell line).
Disease Waldenstrom macroglobulinemia (NCIt: C80307)
Waldenstrom macroglobulinemia (ORDO: Orphanet_33226)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_M086 (MWCL-1)
Sex of cell Male
Age at sampling 73Y
Category Cancer cell line
Publications

PubMed=28548645; DOI=10.1038/bcj.2017.40; PMCID=PMC5518884
Aneel Paulus, Sharoon Akhtar, Hafiz Muhammad Yousaf, Alak Manna, Shumail Marshal Paulus, Yamima Bashir, Thomas R. Caulfield, Maja Kristin Kuranz Blake, Kasyapa S. Chitta, Xue Wang, Yan Asmann ...Show all 15 authors... , Roman Hudec, Wolfdieter Springer, Sikander Ailawadhi, Asher A. Chanan-Khan; Show fewer authors
Waldenstrom macroglobulinemia cells devoid of BTK(C481S) or CXCR4(WHIM-like) mutations acquire resistance to ibrutinib through upregulation of Bcl-2 and AKT resulting in vulnerability towards venetoclax or MK2206 treatment.
Blood Cancer J. 7:e565.1-e565.11(2017)

Cross-references
Cell line databases/resources cancercelllines; CVCL_VJ32
Encyclopedic resources Wikidata; Q95991590
Polymorphism and mutation databases Cosmic; 2645645
Entry history
Entry creation07-Sep-2018
Last entry update14-Aug-2025
Version number11