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Cellosaurus MWCL-1 (CVCL_M086)

[Text version]
Cell line name MWCL-1
Synonyms MWCL.1; MWCL1
Accession CVCL_M086
Resource Identification Initiative To cite this cell line use: MWCL-1 (RRID:CVCL_M086)
Comments Omics: Genomics; Whole genome sequencing.
Omics: Variations; Array-based CGH.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
Disease Waldenstrom macroglobulinemia (NCIt: C80307)
Waldenstrom macroglobulinemia (ORDO: Orphanet_33226)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_VJ31 (MWCL-1/BR)CVCL_VJ32 (MWCL-1/IR)
Sex of cell Male
Age at sampling 73Y
Category Cancer cell line
Publications

PubMed=21415268; DOI=10.1182/blood-2010-12-326868
Lucy S. Hodge, Anne J. Novak, Deanna M. Grote, Esteban Braggio, Rhett P. Ketterling, Michelle K. Manske, Tammy L. Price-Troska, Steven C. Ziesmer, Rafael Fonseca, Thomas E. Witzig, William G. Morice 2nd ...Show all 13 authors... , Morie A. Gertz, Stephen M. Ansell; Show fewer authors
Establishment and characterization of a novel Waldenstrom macroglobulinemia cell line, MWCL-1.
Blood 117:e190-e197(2011)

PubMed=22950966; DOI=10.3109/10428194.2012.727418
Hans Gunther Drexler, Su-Ning Chen, Roderick A.F. MacLeod;
Would the real Waldenstrom cell line please stand up?
Leuk. Lymphoma 54:224-226(2013)

PubMed=23321251; DOI=10.1182/blood-2012-09-454355; PMCID=PMC3596964
Lian Xu, Zachary Richard Hunter, Guang Yang, Yang-Sheng Zhou, Yang Cao, Xia Liu, Enrica Morra, Alessandra Trojani, Antonino Greco, Luca Arcaini, Marzia Varettoni ...Show all 20 authors... , Jennifer R. Brown, Yu-Tzu Tai, Kenneth Carl Anderson, Nikhil C. Munshi, Christopher J. Patterson, Robert J. Manning, Christina K. Tripsas, Neal I. Lindeman, Steven Peter Treon; Show fewer authors
MYD88 L265P in Waldenstrom macroglobulinemia, immunoglobulin M monoclonal gammopathy, and other B-cell lymphoproliferative disorders using conventional and quantitative allele-specific polymerase chain reaction.
Blood 121:2051-2058(2013)

PubMed=24189269; DOI=10.1038/labinvest.2013.129
Naoki Wada, Mao-Sheng Zhan, Yumiko Hori, Keiichiro Honma, Jun-ichiro Ikeda, Eiichi Morii;
Characterization of subpopulation lacking both B-cell and plasma cell markers in Waldenstrom macroglobulinemia cell line.
Lab. Invest. 94:79-88(2014)

PubMed=25382610; DOI=10.1038/bcj.2014.74; PMCID=PMC5424099
Kasyapa S. Chitta, Aneel Paulus, Thomas R. Caulfield, Sharoon Akhtar, Maja Kristin Kuranz Blake, Sikander Ailawadhi, Joshua Knight, Michael G. Heckman, Anthony B. Pinkerton, Asher A. Chanan-Khan;
Nimbolide targets BCL2 and induces apoptosis in preclinical models of Waldenstroms macroglobulinemia.
Blood Cancer J. 4:e260.1-e260.10(2014)

PubMed=25853860; DOI=10.1371/journal.pone.0122338; PMCID=PMC4390194
Aneel Paulus, Kasyapa S. Chitta, Paul K. Wallace, Pooja P. Advani, Sharoon Akhtar, Maja Kristin Kuranz Blake, Sikander Ailawadhi, Asher A. Chanan-Khan;
Immunophenotyping of Waldenstroms macroglobulinemia cell lines reveals distinct patterns of surface antigen expression: potential biological and therapeutic implications.
PLoS ONE 10:e0122338.1-e0122338.17(2015)

PubMed=40254718; DOI=10.1111/bjh.20072
Shi-Rong Liu, Xia Liu, Choudhury Fabliha Binte Yusuf, Amanda Kofides, Kara M. Soroko, Johany Penailillo, Alexa G. Canning, Yang Cao, Guang Yang, Lian Xu, Nicholas Tsakmaklis ...Show all 22 authors... , Hao Sun, Alberto Guijosa, Maria Luisa Guerrera, Christopher J. Patterson, Ruben D. Carrasco, Prafulla C. Gokhale, Shayna Rae Sarosiek, Jorge J. Castillo, John M. Hatcher, Zachary Richard Hunter, Steven Peter Treon; Show fewer authors
Development and characterization of the novel MYD88 mutated, 6q deleted BCWM.2 cell line for Waldenstrom macroglobulinaemia.
Br. J. Haematol. 206:1604-1614(2025)

Cross-references
Cell line databases/resources CLO; CLO_0037225
cancercelllines; CVCL_M086
LINCS_HMS; 51098
LINCS_LDP; LCL-2109
Encyclopedic resources Wikidata; Q28914904
Polymorphism and mutation databases Cosmic; 1762457
Cosmic; 2645644
Entry history
Entry creation06-May-2013
Last entry update14-Aug-2025
Version number18