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Cellosaurus H157R (CVCL_VD88)

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Cell line name H157R
Synonyms NCI H157R
Accession CVCL_VD88
Resource Identification Initiative To cite this cell line use: H157R (RRID:CVCL_VD88)
Comments Problematic cell line: Contaminated. Parent cell line (NCI-H157) has been shown to be identical to NCI-H1264.
Characteristics: Resistant to the polyamine analog N(1),N(12)-diethylspermine.
Knockout cell: Method=Homologous recombination; HGNC; HGNC:10540; SAT1.
Genetic integration: Method=Transfection; Gene=UniProtKB; Q9QNF7; Human herpesvirus 1 TK.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Sequence variations
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.His83Tyr (c.247C>T) (p.Ala97Val, c.290C>T); ClinVar=VCV000376307; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Arg (c.34G>C); ClinVar=VCV000012579; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Leu35Phefs*8 (c.102_103insT) (c.103_104insT); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu298Ter (c.892G>T); ClinVar=VCV000093323; Zygosity=Heterozygous (from parent cell line).
Disease Lung squamous cell carcinoma (NCIt: C3493)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0463 (NCI-H157)
Sex of cell Male
Age at sampling 59Y
Category Cancer cell line
Publications

PubMed=8557774; DOI=10.1002/(SICI)1097-4652(199601)166:1<43::AID-JCP5>3.0.CO;2-G
Dan Shao, Lei Xiao, Hyo-Chol Ha, Robert Anthony Casero Jr.;
Isolation of a polyamine transport deficient cell line from the human non-small cell lung carcinoma line NCI H157.
J. Cell. Physiol. 166:43-48(1996)

Cross-references
Cell line databases/resources cancercelllines; CVCL_VD88
Encyclopedic resources Wikidata; Q54871951
Entry history
Entry creation14-May-2018
Last entry update14-Aug-2025
Version number15