ID   H157R
AC   CVCL_VD88
SY   NCI H157R
DR   cancercelllines; CVCL_VD88
DR   Wikidata; Q54871951
RX   PubMed=8557774;
CC   Problematic cell line: Contaminated. Parent cell line (NCI-H157) has been shown to be identical to NCI-H1264.
CC   Characteristics: Resistant to the polyamine analog N(1),N(12)-diethylspermine.
CC   Knockout cell: Method=Homologous recombination; HGNC; 10540; SAT1.
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; p.His83Tyr (c.247C>T) (p.Ala97Val, c.290C>T); ClinVar=VCV000376307; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Arg (c.34G>C); ClinVar=VCV000012579; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Leu35fs*8 (c.102_103insT) (c.103_104insT); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Glu298Ter (c.892G>T); ClinVar=VCV000093323; Zygosity=Heterozygous (from parent cell line).
CC   Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
DI   NCIt; C3493; Lung squamous cell carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0463 ! NCI-H157
SX   Male
AG   59Y
CA   Cancer cell line
DT   Created: 14-05-18; Last updated: 05-10-23; Version: 11
//
RX   PubMed=8557774; DOI=10.1002/(SICI)1097-4652(199601)166:1<43::AID-JCP5>3.0.CO;2-G;
RA   Shao D., Xiao L., Ha H.-C., Casero R.A. Jr.;
RT   "Isolation of a polyamine transport deficient cell line from the human
RT   non-small cell lung carcinoma line NCI H157.";
RL   J. Cell. Physiol. 166:43-48(1996).
//