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Cellosaurus (CVCL_VA18)

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Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: TCGA-110-CL cell line panel.
Population: Caucasian.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Oral cavity, tongue; UBERON=UBERON_0001723.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Val173_Arg174InsGly (c.518_520delTGA); Zygosity=Homozygous (PubMed=8390283; Cosmic-CLP=1290725; DepMap=ACH-000228).
HLA typing Source: PubMed=26589293
Class I
HLA-AA*32:01,32:01
HLA-BB*07:02,07:02
HLA-CC*07:02,07:02
Genome ancestry Source: PubMed=30894373

Origin% genome
African1.67
Native American0
East Asian, North1.96
East Asian, South0
South Asian0
European, North61.56
European, South34.81
Disease Tongue squamous cell carcinoma (NCIt: C4648)
Squamous cell carcinoma of the oral tongue (ORDO: Orphanet_457252)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=1290725; ECACC=04072107; PubMed=25877200

Markers:
AmelogeninX
CSF1PO9,14
D3S135815
D5S81813
D7S8208,12
D8S117913
D13S31712
D16S53911,12
D18S5116
D21S1128
FGA24
Penta D12
Penta E11
TH019
TPOX10
vWA18

Run an STR similarity search on this cell line
Publications





Kazuaki Kubo, Tomoki Naoe, Kazuhiko R. Utsumi, Yukari Ishiguro, Kazuhiro Ueda, Hiroshi Shiku, Kazumasa Yamada;
Cytogenetic and cellular characteristics of a human embryonal rhabdomyosarcoma cell line, RMS-YM.
Br. J. Cancer 63:879-884(1991)


Daniele Brouty-Boye, Jocelyn Vedrenne, Yasmina Sahraoui, Herve Brailly, Alessandro Poggi, Claude Jasmin, Bruno Azzarone, Francesco Indiveri;
IL2 triggers a tumor progression process in a melanoma cell line MELP derived from a patient whose metastasis increased in size during IL2/INFalpha biotherapy.
Oncogene 12:1015-1023(1996)




Nat. Biotechnol. 26:1269-1275(2008)


Louis Guillou, Philippe Terrier, Alain Aurias;
Strong smooth muscle differentiation is dependent on myocardin gene amplification in most human retroperitoneal leiomyosarcomas.
Cancer Res. 69:2269-2278(2009)


Julie Adam, Ann Hedley, Gabriela Kalna, Ian Philip Mark Tomlinson, Patrick John Pollard, David George Watson, Ralph J. DeBerardinis, Tomer Shlomi, Eytan Ruppin, Eyal Gottlieb;
Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase.
Nature 477:225-228(2011)


Pedro G. Ferreira, Matthias Barann, Thomas Wieland, Liliana Greger, Maarten van Iterson, Jonas Carlsson Almlof, Paolo Ribeca, Irina Pulyakhina, Daniela Esser, Thomas Giger, Andrew Tikhonov ...Show all 48 authors... , Marc Sultan, Gabrielle Bertier, Daniel Geoffrey MacArthur, Monkol Lek, Esther Lizano, Henk P.J. Buermans, Ismael Padioleau, Thomas Schwarzmayr, Olof Karlberg, Halit Ongen, Helena Kilpinen, Sergi Beltran, Marta Gut, Katja Kahlem, Vyacheslav Amstislavskiy, Oliver Stegle, Matti Pirinen, Stephen B. Montgomery, Peter Donnelly, Mark Ian McCarthy, Paul Flicek, Tim-Matthias Strom, Hans Lehrach, Stefan Schreiber, Ralf Sudbrak, Angel Carracedo, Stylianos E. Antonarakis, Robert Hasler, Ann-Christine Syvanen, Gert-Jan B. van Ommen, Alvis Brazma, Thomas Meitinger, Philip Rosenstiel, Roderic Guigo, Ivo G. Gut, Xavier Estivill, Emmanouil Theophilos Dermitzakis; Show fewer authors
Geuvadis Consortium
Transcriptome and genome sequencing uncovers functional variation in humans.
Nature 501:506-511(2013)


Hangnoh Lee, Charles Joel McManus, Dong-Yeon Cho, Matthew Eaton, Fioranna Renda, Maria Patrizia Somma, Lucy Cherbas, Gemma May, Sara Powell, Da-Yu Zhang, Li-Jun Zhan ...Show all 20 authors... , Alissa Resch, Justen Andrews, Susan E. Celniker, Peter Cherbas, Teresa Maria Przytycka, Maurizio Gatti, Brian Oliver, Brenton R. Graveley, David M. MacAlpine; Show fewer authors
DNA copy number evolution in Drosophila cell lines.
Genome Biol. 15:R70.1-R70.20(2014)


Yasuhiro Takashima, Ge Guo, Remco Loos, Jennifer Nichols, Gabriella Ficz, Felix Krueger, David Oxley, Fatima Santos, James Clarke, William Mansfield, Wolf Reik ...Show all 13 authors... , Paul Bertone, Austin Gerard Smith; Show fewer authors
Resetting transcription factor control circuitry toward ground-state pluripotency in human.
Cell 158:1254-1269(2014)



literature.
Cancer Res. 77:2784-2788(2017)


Tetsuhiro Kikuchi, Asuka Morizane, Daisuke Doi, Hiroaki Magotani, Hirotaka Onoe, Takuya Hayashi, Hiroshi Mizuma, Sayuki Takara, Ryosuke Takahashi, Haruhisa Inoue, Satoshi Morita ...Show all 16 authors... , Michio Yamamoto, Keisuke Okita, Masato Nakagawa, Malin Parmar, Jun Takahashi; Show fewer authors
Human iPS cell-derived dopaminergic neurons function in a primate Parkinson's disease model.
Nature 548:592-596(2017)


Thomas B. Hildebrandt, Robert Hermes, Silvia Colleoni, Sebastian Diecke, Susanne Holtze, Marilyn Bernice Renfree, Jan Stejskal, Katsuhiko Hayashi, Micha Drukker, Pasqualino Loi, Frank Goritz ...Show all 13 authors... , Giovanna Lazzari, Cesare Galli; Show fewer authors
Embryos and embryonic stem cells from the white rhinoceros.
Nat. Commun. 9:2589.1-2589.9(2018)




Cancer Cell 33:386-400.e5(2018)


Zhao-Hui Xu, Sylvester Jusu, Sankaranarayanan Kannan, Jing Wang, Alexander J.F. Lazar, Eric J. Earley, Stephen W. Erickson, Tara Gelb, Philip Huxley, Johanna Lahdenranta, Gemma E. Mudd ...Show all 16 authors... , Raushan T. Kurmasheva, Peter J. Houghton, Malcolm A. Smith, Edward Anders Kolb, Richard Greg Gorlick; Show fewer authors
Comprehensive surfaceome profiling to identify and validate novel cell-surface targets in osteosarcoma.
Mol. Cancer Ther. 21:903-913(2022)

Cross-references
Cell line collections (Providers) Ximbio; 152846
Cell line databases/resources LINCS_LDP; LCL-1214
Chemistry resources GDSC; 1290725
PharmacoDB; BICR31_97_2019
Encyclopedic resources Wikidata; Q54796530
Gene expression databases GEO; GSM827311
GEO; GSM886886
GEO; GSM887951
GEO; GSM1669623
Polymorphism and mutation databases IARC_TP53; 28360
LiGeA; CCLE_691
Progenetix; CVCL_2312
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number37