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Cellosaurus HCC827EPR (CVCL_V407)

[Text version]
Cell line name HCC827EPR
Accession CVCL_V407
Resource Identification Initiative To cite this cell line use: HCC827EPR (RRID:CVCL_V407)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:114785; Erlotinib.
Selected for resistance to: ChEBI; CHEBI:90197; PHA-665752.
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; 3236; EGFR; Simple; p.Glu746_Ala750del (c.2236_2250del15); ClinVar=VCV000177620; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Val218del (c.646_648GTG[2]) (c.652_654delGTG); ClinVar=VCV000634761; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2063 (HCC827)
Sex of cell Female
Age at sampling 39Y
Category Cancer cell line

PubMed=21062933; DOI=10.1158/1078-0432.CCR-10-1371
Suda K., Murakami I., Katayama T., Tomizawa K., Osada H., Sekido Y., Maehara Y., Yatabe Y., Mitsudomi T.
Reciprocal and complementary role of MET amplification and EGFR T790M mutation in acquired resistance to kinase inhibitors in lung cancer.
Clin. Cancer Res. 16:5489-5498(2010)

Cell line databases/resources cancercelllines; CVCL_V407
Encyclopedic resources Wikidata; Q54881809
Entry history
Entry creation16-Apr-2014
Last entry update05-Oct-2023
Version number14