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Cellosaurus HCC827CLR (CVCL_V406)

[Text version]
Cell line name HCC827CLR
Accession CVCL_V406
Resource Identification Initiative To cite this cell line use: HCC827CLR (RRID:CVCL_V406)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:90180; CL-387785 (EKI-785).
Selected for resistance to: ChEBI; CHEBI:114785; Erlotinib.
Selected for resistance to: ChEBI; CHEBI:90197; PHA-665752.
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; 3236; EGFR; Simple; p.Glu746_Ala750del (c.2236_2250del15); ClinVar=VCV000177620; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Val218del (c.646_648GTG[2]) (c.652_654delGTG); ClinVar=VCV000634761; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_V407 (HCC827EPR)
Sex of cell Female
Age at sampling 39Y
Category Cancer cell line

PubMed=22133747; DOI=10.1016/j.lungcan.2011.11.007
Suda K., Tomizawa K., Osada H., Maehara Y., Yatabe Y., Sekido Y., Mitsudomi T.
Conversion from the 'oncogene addiction' to 'drug addiction' by intensive inhibition of the EGFR and MET in lung cancer with activating EGFR mutation.
Lung Cancer 76:292-299(2012)

Cell line databases/resources cancercelllines; CVCL_V406
Encyclopedic resources Wikidata; Q54881808
Polymorphism and mutation databases Cosmic; 1604992
Entry history
Entry creation16-Apr-2014
Last entry update05-Oct-2023
Version number14