Cellosaurus logo
expasy logo

Cellosaurus HCC827CLR (CVCL_V406)

[Text version]
Cell line name HCC827CLR
Accession CVCL_V406
Resource Identification Initiative To cite this cell line use: HCC827CLR (RRID:CVCL_V406)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_90180; CL-387785 (EKI-785).
Selected for resistance to: ChEBI; CHEBI_114785; Erlotinib.
Selected for resistance to: ChEBI; CHEBI_90197; PHA-665752.
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Glu746_Ala750del (c.2236_2250del15); ClinVar=VCV000177620; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Val218del (c.646_648GTG[2]) (c.652_654delGTG); ClinVar=VCV000634761; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_V407 (HCC827EPR)
Sex of cell Female
Age at sampling 39Y
Category Cancer cell line
Publications

PubMed=22133747; DOI=10.1016/j.lungcan.2011.11.007
Kenichi Suda, Kenji Tomizawa, Hirotaka Osada, Yoshihiko Maehara, Yasushi Yatabe, Yoshitaka Sekido, Tetsuya Mitsudomi;
Conversion from the 'oncogene addiction' to 'drug addiction' by intensive inhibition of the EGFR and MET in lung cancer with activating EGFR mutation.
Lung Cancer 76:292-299(2012)

Cross-references
Cell line databases/resources cancercelllines; CVCL_V406
Encyclopedic resources Wikidata; Q54881808
Polymorphism and mutation databases Cosmic; 1604992
Entry history
Entry creation16-Apr-2014
Last entry update19-Dec-2024
Version number15