| Cell line name |
CCRF-CEM R30dm |
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| Synonyms |
R30dm-CCRF-CEM; R30dm |
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| Accession |
CVCL_V325 |
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| Resource Identification Initiative |
To cite this cell line use: CCRF-CEM R30dm (RRID:CVCL_V325) |
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| Comments |
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:44185; Methotrexate (MTX).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084. |
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| Sequence variations |
- Gene fusion; HGNC; 13222; BCL11B + HGNC; 2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
- Mutation; HGNC; 16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
|
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| Disease |
Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_V323 (CCRF-CEM R30/6) |
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| Sex of cell |
Female |
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| Age at sampling |
3Y11M |
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| Category |
Cancer cell line |
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| Publications | PubMed=2007575; DOI=10.1016/S0021-9258(18)38101-8
McCloskey D.E., McGuire J.J., Russell C.A., Rowan B.G., Bertino J.R., Pizzorno G., Mini E.
Decreased folylpolyglutamate synthetase activity as a mechanism of methotrexate resistance in CCRF-CEM human leukemia sublines.
J. Biol. Chem. 266:6181-6187(1991) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_V325
|
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| Chemistry resources |
ChEMBL-Cells; CHEMBL3307546
ChEMBL-Targets; CHEMBL614143
PubChem_Cell_line; CVCL_V325
|
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| Encyclopedic resources |
Wikidata; Q54809023
|
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| Entry history |
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| Entry creation | 16-Apr-2014 |
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| Last entry update | 05-Oct-2023 |
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| Version number | 20 |
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