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Cellosaurus CCRF-CEM R30dm (CVCL_V325)

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Cell line name CCRF-CEM R30dm
Synonyms R30dm-CCRF-CEM; R30dm
Accession CVCL_V325
Resource Identification Initiative To cite this cell line use: CCRF-CEM R30dm (RRID:CVCL_V325)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_44185; Methotrexate (MTX).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Gene fusion; HGNC; HGNC:13222; BCL11B + HGNC; HGNC:2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
  • Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_V323 (CCRF-CEM R30/6)
Sex of cell Female
Age at sampling 3Y11M
Category Cancer cell line
Publications

PubMed=2007575; DOI=10.1016/S0021-9258(18)38101-8
Diane E. McCloskey, John J. McGuire, Cynthia A. Russell, Brian G. Rowan, Joseph Rocco Bertino, Giuseppe Pizzorno, Enrico Mini;
Decreased folylpolyglutamate synthetase activity as a mechanism of methotrexate resistance in CCRF-CEM human leukemia sublines.
J. Biol. Chem. 266:6181-6187(1991)

Cross-references
Cell line databases/resources cancercelllines; CVCL_V325
Chemistry resources ChEMBL-Cells; CHEMBL3307546
ChEMBL-Targets; CHEMBL614143
PubChem_Cell_line; CVCL_V325
Encyclopedic resources Wikidata; Q54809023
Entry history
Entry creation16-Apr-2014
Last entry update19-Dec-2024
Version number21