ID   CCRF-CEM R30dm
AC   CVCL_V325
SY   R30dm-CCRF-CEM; R30dm
DR   cancercelllines; CVCL_V325
DR   ChEMBL-Cells; CHEMBL3307546
DR   ChEMBL-Targets; CHEMBL614143
DR   PubChem_Cell_line; CVCL_V325
DR   Wikidata; Q54809023
RX   PubMed=2007575;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI:44185; Methotrexate (MTX).
CC   Sequence variation: Gene fusion; HGNC; 13222; BCL11B + HGNC; 2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: T-cell; CL=CL_0000084.
DI   NCIt; C7953; Childhood T acute lymphoblastic leukemia
DI   ORDO; Orphanet_99861; Precursor T-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_V323 ! CCRF-CEM R30/6
SX   Female
AG   3Y11M
CA   Cancer cell line
DT   Created: 16-04-14; Last updated: 05-10-23; Version: 20
//
RX   PubMed=2007575; DOI=10.1016/S0021-9258(18)38101-8;
RA   McCloskey D.E., McGuire J.J., Russell C.A., Rowan B.G., Bertino J.R.,
RA   Pizzorno G., Mini E.;
RT   "Decreased folylpolyglutamate synthetase activity as a mechanism of
RT   methotrexate resistance in CCRF-CEM human leukemia sublines.";
RL   J. Biol. Chem. 266:6181-6187(1991).
//