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Cellosaurus KH88 B4D6 (CVCL_V005)

[Text version]
Cell line name KH88 B4D6
Synonyms KH88-B4D6; KH88 subclone B4D6; KH88B4D6; B4D6
Accession CVCL_V005
Resource Identification Initiative To cite this cell line use: KH88 B4D6 (RRID:CVCL_V005)
Comments Population: Japanese.
Doubling time: 20-26 hours (PubMed=8289484).
Microsatellite instability: Stable (MSS) (PubMed=10739008; PubMed=11226526).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene fusion; HGNC; 76; ABL1 + HGNC; 1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (PubMed=10071072; PubMed=10576511).
Disease Chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C3174)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_G364 (KH88)
Sex of cell Male
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=8289484
Furukawa T., Koike T., Ying W., Kishi K., Aoki S., Gotoh T., Hashimoto S., Saitoh H., Hanano M., Shinada S., Moriyama Y., Takahashi M., Endo Y., Okano H., Maekawa T., Abe T., Shibata A.
Establishment of a new cell line with the characteristics of a multipotential progenitor from a patient with chronic myelogenous leukemia in early erythroblastic crisis.
Leukemia 8:171-180(1994)

PubMed=9644295; DOI=10.1159/000040837
Kaneko H., Horiike S., Sasai Y., Iwai T., Nakao M., Yokota S., Taniwaki M., Kashima K., Misawa S.-i.
Rare alteration of genomic structure or expression of the DPC4 gene in myelogenous leukemias.
Acta Haematol. 99:187-190(1998)

PubMed=10071072; DOI=10.1016/S0145-2126(98)00171-4
Drexler H.G., MacLeod R.A.F., Uphoff C.C.
Leukemia cell lines: in vitro models for the study of Philadelphia chromosome-positive leukemia.
Leuk. Res. 23:207-215(1999)

PubMed=10576511; DOI=10.1016/s0145-2126(99)00131-9
Uphoff C.C., Habig S., Fombonne S., Matsuo Y., Drexler H.G.
ABL-BCR expression in BCR-ABL-positive human leukemia cell lines.
Leuk. Res. 23:1055-1060(1999)

PubMed=10739008; DOI=10.1016/S0145-2126(99)00182-4
Inoue K., Kohno T., Takakura S., Hayashi Y., Mizoguchi H., Yokota J.
Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines.
Leuk. Res. 24:255-262(2000)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=11226526; DOI=10.1016/S0145-2126(00)00121-1
Inoue K., Kohno T., Takakura S., Hayashi Y., Mizoguchi H., Yokota J.
Corrigendum to: Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines Leukemia Research 24 (2000),255-262.
Leuk. Res. 25:275-278(2001)

PubMed=14603991; DOI=10.1081/IMM-120025102
Ayres F.M., Narita M., Takahashi M., Alldawi L., Liu A.-C., Osman Y., Abe T., Yano T., Sakaue M., Toba K., Furukawa T., Aizawa Y.
A comparative study of the JAM test and 51Cr-release assay to assess the cytotoxicity of dendritic cells on hematopoietic tumor cells.
Immunol. Invest. 32:219-227(2003)

Cross-references
Encyclopedic resources Wikidata; Q54899864
Polymorphism and mutation databases Cosmic; 949097
Entry history
Entry creation16-Apr-2014
Last entry update02-May-2024
Version number12