ID   KH88 B4D6
AC   CVCL_V005
SY   KH88-B4D6; KH88 subclone B4D6; KH88B4D6; B4D6
DR   Cosmic; 949097
DR   Wikidata; Q54899864
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=8289484;
RX   PubMed=9644295;
RX   PubMed=10071072;
RX   PubMed=10576511;
RX   PubMed=10739008;
RX   PubMed=11226526;
RX   PubMed=14603991;
CC   Population: Japanese.
CC   Doubling time: 20-26 hours (PubMed=8289484).
CC   Microsatellite instability: Stable (MSS) (PubMed=10739008; PubMed=11226526).
CC   Sequence variation: Gene fusion; HGNC; 76; ABL1 + HGNC; 1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (PubMed=10071072; PubMed=10576511).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
DI   NCIt; C3174; Chronic myelogenous leukemia, BCR-ABL1 positive
DI   ORDO; Orphanet_521; Chronic myeloid leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_G364 ! KH88
SX   Male
AG   69Y
CA   Cancer cell line
DT   Created: 16-04-14; Last updated: 02-05-24; Version: 12
//
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler H.G.;
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001).
//
RX   PubMed=8289484;
RA   Furukawa T., Koike T., Ying W., Kishi K., Aoki S., Gotoh T.,
RA   Hashimoto S., Saitoh H., Hanano M., Shinada S., Moriyama Y.,
RA   Takahashi M., Endo Y., Okano H., Maekawa T., Abe T., Shibata A.;
RT   "Establishment of a new cell line with the characteristics of a
RT   multipotential progenitor from a patient with chronic myelogenous
RT   leukemia in early erythroblastic crisis.";
RL   Leukemia 8:171-180(1994).
//
RX   PubMed=9644295; DOI=10.1159/000040837;
RA   Kaneko H., Horiike S., Sasai Y., Iwai T., Nakao M., Yokota S.,
RA   Taniwaki M., Kashima K., Misawa S.-i.;
RT   "Rare alteration of genomic structure or expression of the DPC4 gene
RT   in myelogenous leukemias.";
RL   Acta Haematol. 99:187-190(1998).
//
RX   PubMed=10071072; DOI=10.1016/S0145-2126(98)00171-4;
RA   Drexler H.G., MacLeod R.A.F., Uphoff C.C.;
RT   "Leukemia cell lines: in vitro models for the study of Philadelphia
RT   chromosome-positive leukemia.";
RL   Leuk. Res. 23:207-215(1999).
//
RX   PubMed=10576511; DOI=10.1016/s0145-2126(99)00131-9;
RA   Uphoff C.C., Habig S., Fombonne S., Matsuo Y., Drexler H.G.;
RT   "ABL-BCR expression in BCR-ABL-positive human leukemia cell lines.";
RL   Leuk. Res. 23:1055-1060(1999).
//
RX   PubMed=10739008; DOI=10.1016/S0145-2126(99)00182-4;
RA   Inoue K., Kohno T., Takakura S., Hayashi Y., Mizoguchi H., Yokota J.;
RT   "Frequent microsatellite instability and BAX mutations in T cell acute
RT   lymphoblastic leukemia cell lines.";
RL   Leuk. Res. 24:255-262(2000).
//
RX   PubMed=11226526; DOI=10.1016/S0145-2126(00)00121-1;
RA   Inoue K., Kohno T., Takakura S., Hayashi Y., Mizoguchi H., Yokota J.;
RT   "Corrigendum to: Frequent microsatellite instability and BAX mutations
RT   in T cell acute lymphoblastic leukemia cell lines Leukemia Research 24
RT   (2000),255-262.";
RL   Leuk. Res. 25:275-278(2001).
//
RX   PubMed=14603991; DOI=10.1081/IMM-120025102;
RA   Ayres F.M., Narita M., Takahashi M., Alldawi L., Liu A.-C., Osman Y.,
RA   Abe T., Yano T., Sakaue M., Toba K., Furukawa T., Aizawa Y.;
RT   "A comparative study of the JAM test and 51Cr-release assay to assess
RT   the cytotoxicity of dendritic cells on hematopoietic tumor cells.";
RL   Immunol. Invest. 32:219-227(2003).
//