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Cellosaurus Huh7 IFITM2-/- (CVCL_UZ56)

[Text version]
Cell line name Huh7 IFITM2-/-
Accession CVCL_UZ56
Resource Identification Initiative To cite this cell line use: Huh7 IFITM2-/- (RRID:CVCL_UZ56)
Comments Population: Japanese.
Knockout cell: Method=CRISPR/Cas9; HGNC; 5413; IFITM2.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; 6307; KDR; Simple; p.Gln472His (c.1416A>T); ClinVar=VCV000134603; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 20932; POLD3; Simple; p.Lys109Arg (c.326A>G) (p.Lys70Arg, c.209A>G); Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Tyr220Cys (c.659A>G); ClinVar=VCV000127819; Zygosity=Homozygous (from parent cell line).
Disease Adult hepatocellular carcinoma (NCIt: C7956)
Adult hepatocellular carcinoma (ORDO: Orphanet_210159)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0336 (Huh-7)
Sex of cell Male
Age at sampling 57Y
Category Cancer cell line

PubMed=30723923; DOI=10.1002/hep.30548
Shi Y., Du L.-Y., Lv D.-D., Li H., Shang J., Lu J.-J., Zhou L.-Y., Bai L., Tang H.
Exosomal IFITM2 transmitted to DCs inhibits IFNalpha pathway activation and blocks anti-HBV efficacy of exogenous IFNalpha.
Hepatology 69:2396-2413(2019)

Cell line databases/resources cancercelllines; CVCL_UZ56
Encyclopedic resources Wikidata; Q94308822
Entry history
Entry creation25-Feb-2019
Last entry update05-Oct-2023
Version number10