Cellosaurus cell line HCB-514 (CVCL

Cellosaurus HCB-514 (CVCL_UZ55)

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Cell line name

HCB-514

Synonyms

Hospital de Cancer de Barretos-514

Accession

CVCL_UZ55

Resource Identification Initiative

To cite this cell line use: HCB-514 (RRID:CVCL_UZ55)

Comments

Virology: Contains HPV16 genomes integrated at two separate chromosomal locations (PubMed=30760827).
Doubling time: 18 hours (Note=In 10% FBS), 24 hours (Note=In 5% FBS) (PubMed=30760827).
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Omics: Genomics; Whole exome sequencing.
Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.

Sequence variations

Mutation; HGNC; HGNC:1101; BRCA2; Simple; p.Trp2830Ter (c.8490G>A); ClinVar=VCV000155722; Zygosity=Heterozygous (PubMed=30760827).
Mutation; HGNC; HGNC:14359; IRX2; Simple; p.Tyr48Ter (c.144T>G); Zygosity=Heterozygous (PubMed=30760827).
Mutation; HGNC; HGNC:11772; TGFBR1; Simple; p.Ala202Val (c.605C>T); ClinVar=VCV000635251; Zygosity=Heterozygous (PubMed=30760827).

Disease

Human papillomavirus-related endocervical adenocarcinoma (NCIt: C27677)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Female

Age at sampling

30Y

Category

Cancer cell line

STR profile

Source(s): PubMed=30760827

Markers:

Amelogenin	X
CSF1PO	12
D5S818	10,12
D7S820	13
D13S317	9,11
D16S539	9
TH01	7,9
TPOX	8,12
vWA	16

Publications

PubMed=30760827; DOI=10.1038/s41598-018-38315-7; PMCID=PMC6374403
Marcela Nunes Rosa, Adriane Feijo Evangelista, Leticia Ferro Leal, Cristina Mendes de Oliveira, Viviane Aline Oliveira Silva, Carla Carolina Munari, Fernanda Franco Munari, Graziela de Macedo Matsushita, Ricardo dos Reis, Carlos Eduardo Andrade, Cristiano de Padua Souza, Rui Manuel Reis;
Establishment, molecular and biological characterization of HCB-514: a novel human cervical cancer cell line.
Sci. Rep. 9:1913.1-1913.13(2019)

Cross-references

Cell line databases/resources

cancercelllines; CVCL_UZ55

Encyclopedic resources

Wikidata; Q93981608

Entry history

Entry creation

25-Feb-2019

Last entry update

10-Apr-2025

Version number