ID   HCB-514
AC   CVCL_UZ55
SY   Hospital de Cancer de Barretos-514
DR   cancercelllines; CVCL_UZ55
DR   Wikidata; Q93981608
RX   PubMed=30760827;
CC   Virology: Contains HPV16 genomes integrated at two separate chromosomal locations (PubMed=30760827).
CC   Doubling time: 18 hours (Note=In 10% FBS), 24 hours (Note=In 5% FBS) (PubMed=30760827).
CC   Sequence variation: Mutation; HGNC; HGNC:1101; BRCA2; Simple; p.Trp2830Ter (c.8490G>A); ClinVar=VCV000155722; Zygosity=Heterozygous (PubMed=30760827).
CC   Sequence variation: Mutation; HGNC; HGNC:14359; IRX2; Simple; p.Tyr48Ter (c.144T>G); Zygosity=Heterozygous (PubMed=30760827).
CC   Sequence variation: Mutation; HGNC; HGNC:11772; TGFBR1; Simple; p.Ala202Val (c.605C>T); ClinVar=VCV000635251; Zygosity=Heterozygous (PubMed=30760827).
CC   Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
CC   Omics: Genomics; Whole exome sequencing.
CC   Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
ST   Source(s): PubMed=30760827
ST   Amelogenin: X
ST   CSF1PO: 12
ST   D13S317: 9,11
ST   D16S539: 9
ST   D5S818: 10,12
ST   D7S820: 13
ST   TH01: 7,9
ST   TPOX: 8,12
ST   vWA: 16
DI   NCIt; C27677; Human papillomavirus-related endocervical adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   30Y
CA   Cancer cell line
DT   Created: 25-02-19; Last updated: 10-04-25; Version: 11
//
RX   PubMed=30760827; DOI=10.1038/s41598-018-38315-7; PMCID=PMC6374403;
RA   Rosa M.N., Evangelista A.F., Leal L.F., de Oliveira C.M.,
RA   Silva V.A.O., Munari C.C., Munari F.F., de Macedo Matsushita G.,
RA   dos Reis R., Andrade C.E., de Padua Souza C., Reis R.M.;
RT   "Establishment, molecular and biological characterization of HCB-514:
RT   a novel human cervical cancer cell line.";
RL   Sci. Rep. 9:1913.1-1913.13(2019).
//