Cellosaurus logo
expasy logo

Cellosaurus K107-Ep/p53DD/TERT (CVCL_UZ34)

[Text][XML][JSON]
Cell line name K107-Ep/p53DD/TERT
Synonyms K107/p53DD/TERT
Accession CVCL_UZ34
Resource Identification Initiative To cite this cell line use: K107-Ep/p53DD/TERT (RRID:CVCL_UZ34)
Comments Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
Genetic integration: Method=Transduction; Gene=MGI; MGI:98834; Trp53 (Note=With p.Leu14_Lys302del = p53DD).
Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
Derived from site: In situ; Skin, epidermis; UBERON=UBERON_0001003.
Cell type: Keratinocyte; CL=CL_0000312.
Sequence variations
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Gly101Trp (c.301G>T) (p.Arg115Leu, c.344G>T); ClinVar=VCV000009412; Zygosity=Hemizygous (PubMed=12077343).
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_UZ33 (K107-Ep)
Sex of cell Female
Age at sampling 52Y
Category Telomerase immortalized cell line
Web pages Provider; BWH dermatology; -; https://dermatology.bwh.harvard.edu/docs/Cell-Culture-Core-Cell-Lines.pdf
Publications

PubMed=12077343; DOI=10.1128/mcb.22.14.5157-5172.2002; PMCID=PMC139780
James George Rheinwald, William Chun Hahn, Matthew Robert Ramsey, Jenny Y. Wu, Zong-You Guo, Hensin Tsao, Michele De Luca, Caterina Catricala, Kathleen M. O'Toole;
A two-stage, p16(INK4A)- and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status.
Mol. Cell. Biol. 22:5157-5172(2002)

Cross-references
Encyclopedic resources Wikidata; Q94334184
Entry history
Entry creation25-Feb-2019
Last entry update14-Aug-2025
Version number12