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Cellosaurus K107-Ep (CVCL_UZ33)

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Cell line name K107-Ep
Synonyms K107
Accession CVCL_UZ33
Resource Identification Initiative To cite this cell line use: K107-Ep (RRID:CVCL_UZ33)
Comments Senescence: Senesces at 55 PDL (PubMed=12077343).
Derived from site: In situ; Skin, epidermis; UBERON=UBERON_0001003.
Cell type: Keratinocyte; CL=CL_0000312.
Sequence variations
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Gly101Trp (c.301G>T) (p.Arg115Leu, c.344G>T); ClinVar=VCV000009412; Zygosity=Heterozygous (PubMed=12077343).
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_UZ34 (K107-Ep/p53DD/TERT)
Sex of cell Female
Age at sampling 52Y
Category Finite cell line
Web pages Provider; BWH dermatology; -; https://dermatology.bwh.harvard.edu/docs/Cell-Culture-Core-Cell-Lines.pdf
Publications

PubMed=12077343; DOI=10.1128/mcb.22.14.5157-5172.2002; PMCID=PMC139780
James George Rheinwald, William Chun Hahn, Matthew Robert Ramsey, Jenny Y. Wu, Zong-You Guo, Hensin Tsao, Michele De Luca, Caterina Catricala, Kathleen M. O'Toole;
A two-stage, p16(INK4A)- and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status.
Mol. Cell. Biol. 22:5157-5172(2002)

Cross-references
Encyclopedic resources Wikidata; Q94334180
Entry history
Entry creation25-Feb-2019
Last entry update10-Apr-2025
Version number11