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Cellosaurus HC0597 (CVCL_UZ31)

[Text version]
Cell line name HC0597
Synonyms HCO597
Accession CVCL_UZ31
Resource Identification Initiative To cite this cell line use: HC0597 (RRID:CVCL_UZ31)
Comments Group: Patented cell line.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-12658.
Doubling time: 31.7 +- 0.5 hours (Patent=US6030789).
Genetic integration: Method=Transfection; Gene=UniProtKB; P03070; SV40 large T antigen.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=pRSV-T).
Anecdotal: Developed and patented by Gillette as a model to replace the Draize rabbit eye test for evaluation of the eye irritation potential of products.
Derived from site: In situ; Eye, conjunctival epithelium; UBERON=UBERON_0006763.
Cell type: Epithelial cell of conjunctiva; CL=CL_1000432.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling Age unspecified
Category Transformed cell line
STR profile Source(s): PubMed=29787296

Markers:
AmelogeninX
D3S135816,17
D5S81812,13
D7S82010,11
D8S117913,16
D13S31711,12
D16S53910
D18S5123,24
D21S1128,32.3
FGA22
Penta D5,9
Penta E12
TH016,9
TPOX8
vWA16,19

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Publications

CLPUB00479
Ward S.L., Walker T.L., Trocme S.D., Hallberg C.K., Kruszewski F.H., DiPasquale L.C.
Tight epithelial barrier established by transfected human conjunctival cell lines.
Invest. Ophthalmol. Vis. Sci. 39:S85-S85(1998)

Patent=US6030789
Ward S.L., Walker T.L.
Human conjunctival epithelial cell lines with an extended life span.
Patent number US6030789, 29-Feb-2000

PubMed=29787296; DOI=10.1080/02713683.2018.1480043; PMCID=PMC6590053
McDermott A.M., Baidouri H., Woodward A.M., Kam W.R., Liu Y., Chen X.-M., Ziemanski J.F., Vistisen K., Hazlett L.D., Nichols K.K., Argueso P., Sullivan D.A.
Short tandem repeat (STR) profiles of commonly used human ocular surface cell lines.
Curr. Eye Res. 43:1097-1101(2018)

Cross-references
Encyclopedic resources Wikidata; Q93981246
Entry history
Entry creation25-Feb-2019
Last entry update19-Dec-2024
Version number12