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Cellosaurus KPC-CRISPR/Cas9 empty plasmid (CVCL_UY60)

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Cell line name KPC-CRISPR/Cas9 empty plasmid
Accession CVCL_UY60
Resource Identification Initiative To cite this cell line use: KPC-CRISPR/Cas9 empty plasmid (RRID:CVCL_UY60)
Comments Characteristics: Control cell line for KPC-IL-6 KO (Cellosaurus=CVCL_UR56). Transfected with a CRISPR/Cas9 empty plasmid.
Derived from site: In situ; Pancreas; UBERON=UBERON_0001264.
Sequence variations
  • Mutation; MGI; MGI:96680; Kras; Simple; p.Gly12Asp (c.35G>A); Zygosity=Unspecified (from inference of genetic background of transgenic mouse used).
  • Mutation; MGI; MGI:98834; Trp53; Simple; p.Arg270His (c.809G>A); Zygosity=Unspecified (from inference of genetic background of transgenic mouse used).
Disease Mouse pancreatic ductal adenocarcinoma (NCIt: C34041)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: LSL-KrasG12D:LSL-Trp53R172H:Pdx1-Cre (KPC).
Sex of cell Male
Category Cancer cell line
Publications

PubMed=33851955; DOI=10.1084/jem.20190450; PMCID=PMC8185651
Joseph Emil Rupert, Ashok Narasimhan, Daenique H.A. Jengelley, Yan-Lin Jiang, Jian-Guo Liu, Ernie Au, Libbie M. Silverman, George Sandusky, Andrea Bonetto, Sha Cao, Xiao-Yu Lu ...Show all 15 authors... , Thomas M. O'Connell, Yun-Long Liu, Leonidas G. Koniaris, Teresa A. Zimmers-Koniaris; Show fewer authors
Tumor-derived IL-6 and trans-signaling among tumor, fat, and muscle mediate pancreatic cancer cachexia.
J. Exp. Med. 218:e20190450.1-e20190450.23(2021)

Cross-references
Encyclopedic resources Wikidata; Q95980096
Entry history
Entry creation25-Feb-2019
Last entry update14-Aug-2025
Version number6