Cellosaurus cell line KPC-IL-6 KO (CVCL

Cross-references
Cell line name	KPC-IL-6 KO
Synonyms	KPC-IL-6KO
Accession	CVCL_UR56
Resource Identification Initiative	To cite this cell line use: KPC-IL-6 KO (RRID:CVCL_UR56)
Comments	Knockout cell: Method=CRISPR/Cas9; MGI; MGI:96559; Il6. Derived from site: In situ; Pancreas; UBERON=UBERON_0001264.
Sequence variations	Mutation; MGI; MGI:96680; Kras; Simple; p.Gly12Asp (c.35G>A); Zygosity=Unspecified (from inference of genetic background of transgenic mouse used). Mutation; MGI; MGI:98834; Trp53; Simple; p.Arg270His (c.809G>A); Zygosity=Unspecified (from inference of genetic background of transgenic mouse used).
Disease	Mouse pancreatic ductal adenocarcinoma (NCIt: C34041)
Species of origin	Mus musculus (Mouse) (NCBI Taxonomy: 10090) Breed/subspecies: LSL-KrasG12D:LSL-Trp53R172H:Pdx1-Cre (KPC).
Sex of cell	Male
Category	Cancer cell line
Publications	PubMed=33851955; DOI=10.1084/jem.20190450; PMCID=PMC8185651 Joseph Emil Rupert, Ashok Narasimhan, Daenique H.A. Jengelley, Yan-Lin Jiang, Jian-Guo Liu, Ernie Au, Libbie M. Silverman, George Sandusky, Andrea Bonetto, Sha Cao, Xiao-Yu Lu ...Show all 15 authors... , Thomas M. O'Connell, Yun-Long Liu, Leonidas G. Koniaris, Teresa A. Zimmers-Koniaris; Show fewer authors Tumor-derived IL-6 and trans-signaling among tumor, fat, and muscle mediate pancreatic cancer cachexia. J. Exp. Med. 218:e20190450.1-e20190450.23(2021)
Encyclopedic resources	Wikidata; Q95980100
Entry history
Entry creation	25-Feb-2019
Last entry update	14-Aug-2025
Version number	6