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Cellosaurus KPC-IL-6 KO (CVCL_UR56)

[Text version]
Cell line name KPC-IL-6 KO
Synonyms KPC-IL-6KO
Accession CVCL_UR56
Resource Identification Initiative To cite this cell line use: KPC-IL-6 KO (RRID:CVCL_UR56)
Comments Knockout cell: Method=CRISPR/Cas9; MGI; MGI:96559; Il6.
Genetic integration: Method=Transgenic mouse; Gene=MGI; MGI:96680; Kras (Note=With p.Gly12Asp).
Derived from site: In situ; Pancreas; UBERON=UBERON_0001264.
Disease Mouse pancreatic ductal adenocarcinoma (NCIt: C34041)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: LSL-KrasG12D:LSL-Trp53R172H:Pdx1-Cre (KPC).
Sex of cell Male
Category Cancer cell line
Publications

PubMed=33851955; DOI=10.1084/jem.20190450; PMCID=PMC8185651
Rupert J.E., Narasimhan A., Jengelley D.H.A., Jiang Y.-L., Liu J.-G., Au E., Silverman L.M., Sandusky G., Bonetto A., Cao S., Lu X.-Y., O'Connell T.M., Liu Y.-L., Koniaris L.G., Zimmers-Koniaris T.A.
Tumor-derived IL-6 and trans-signaling among tumor, fat, and muscle mediate pancreatic cancer cachexia.
J. Exp. Med. 218:e20190450.1-e20190450.23(2021)

Cross-references
Encyclopedic resources Wikidata; Q95980100
Entry history
Entry creation25-Feb-2019
Last entry update10-Sep-2024
Version number5