Cell line name |
H460R |
Accession |
CVCL_UW76 |
Resource Identification Initiative |
To cite this cell line use: H460R (RRID:CVCL_UW76) |
Comments |
Population: Caucasian. Characteristics: Established from parent cell line after 40 repetitive irradiation dose of 2 Gy each. Selected for resistance to: NCIt; C44386; Gamma radiation. Omics: Transcriptomics; Microarray. Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175. |
Sequence variations |
- Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gln61His (c.183A>T); ClinVar=VCV000045117; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).
|
Disease |
Lung large cell carcinoma (NCIt: C4450) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_0459 (NCI-H460) |
Sex of cell |
Male |
Age at sampling |
Age unspecified |
Category |
Cancer cell line |
Publications | PubMed=20510196; DOI=10.1016/j.ijrobp.2009.12.076 Young Sook Lee, Jung-Hwa Oh, Seokjoo Yoon, Myung-Sang Kwon, Chang-Woo Song, Ki-Hwan Kim, Moon-June Cho, Mohamad Lalmodin Mollah, Young Jin Je, Yoon-Dong Kim, Chang Deok Kim, Jeung-Hoon Lee; Differential gene expression profiles of radioresistant non-small-cell lung cancer cell lines established by fractionated irradiation: tumor protein p53-inducible protein 3 confers sensitivity to ionizing radiation. Int. J. Radiat. Oncol. Biol. Phys. 77:858-866(2010) PubMed=24465237; DOI=10.5808/GI.2013.11.4.245; PMCID=PMC3897853 Chang-Nim Im, Byeong Mo Kim, Eun-Yi Moon, Da-Won Hong, Joung Whan Park, Sung Hee Hong; Characterization of H460R, a radioresistant human lung cancer cell line, and involvement of syntrophin beta 2 (SNTB2) in radioresistance. Genomics Inform. 11:245-253(2013) |
Cross-references |
Cell line databases/resources |
cancercelllines; CVCL_UW76
|
Encyclopedic resources |
Wikidata; Q93936856
|
Entry history |
Entry creation | 25-Feb-2019 |
Last entry update | 10-Apr-2025 |
Version number | 9 |
---|