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Cellosaurus H460R (CVCL_UW76)

[Text version]
Cell line name H460R
Accession CVCL_UW76
Resource Identification Initiative To cite this cell line use: H460R (RRID:CVCL_UW76)
Comments Population: Caucasian.
Characteristics: Established from parent cell line after 40 repetitive irradiation dose of 2 Gy each.
Selected for resistance to: NCIt; C44386; Gamma radiation.
Omics: Transcriptome analysis by microarray.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gln61His (c.183A>T); ClinVar=VCV000045117; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).
Disease Lung large cell carcinoma (NCIt: C4450)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0459 (NCI-H460)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line

PubMed=20510196; DOI=10.1016/j.ijrobp.2009.12.076
Lee Y.S., Oh J.-H., Yoon S., Kwon M.-S., Song C.-W., Kim K.-H., Cho M.-J., Mollah M.L., Je Y.J., Kim Y.-D., Kim C.D., Lee J.-H.
Differential gene expression profiles of radioresistant non-small-cell lung cancer cell lines established by fractionated irradiation: tumor protein p53-inducible protein 3 confers sensitivity to ionizing radiation.
Int. J. Radiat. Oncol. Biol. Phys. 77:858-866(2010)

PubMed=24465237; DOI=10.5808/GI.2013.11.4.245
Im C.-N., Kim B.M., Moon E.-Y., Hong D.-W., Park J.W., Hong S.H.
Characterization of H460R, a radioresistant human lung cancer cell line, and involvement of syntrophin beta 2 (SNTB2) in radioresistance.
Genomics Inform. 11:245-253(2013)

Cell line databases/resources cancercelllines; CVCL_UW76
Encyclopedic resources Wikidata; Q93936856
Entry history
Entry creation25-Feb-2019
Last entry update05-Oct-2023
Version number7