ID   H460R
AC   CVCL_UW76
DR   cancercelllines; CVCL_UW76
DR   Wikidata; Q93936856
RX   PubMed=20510196;
RX   PubMed=24465237;
CC   Population: Caucasian.
CC   Characteristics: Established from parent cell line after 40 repetitive irradiation dose of 2 Gy each.
CC   Selected for resistance to: NCIt; C44386; Gamma radiation.
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gln61His (c.183A>T); ClinVar=VCV000045117; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C4450; Lung large cell carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0459 ! NCI-H460
SX   Male
AG   Age unspecified
CA   Cancer cell line
DT   Created: 25-02-19; Last updated: 05-10-23; Version: 7
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RX   PubMed=20510196; DOI=10.1016/j.ijrobp.2009.12.076;
RA   Lee Y.S., Oh J.-H., Yoon S., Kwon M.-S., Song C.-W., Kim K.-H.,
RA   Cho M.-J., Mollah M.L., Je Y.J., Kim Y.-D., Kim C.D., Lee J.-H.;
RT   "Differential gene expression profiles of radioresistant
RT   non-small-cell lung cancer cell lines established by fractionated
RT   irradiation: tumor protein p53-inducible protein 3 confers sensitivity
RT   to ionizing radiation.";
RL   Int. J. Radiat. Oncol. Biol. Phys. 77:858-866(2010).
//
RX   PubMed=24465237; DOI=10.5808/GI.2013.11.4.245;
RA   Im C.-N., Kim B.M., Moon E.-Y., Hong D.-W., Park J.W., Hong S.H.;
RT   "Characterization of H460R, a radioresistant human lung cancer cell
RT   line, and involvement of syntrophin beta 2 (SNTB2) in
RT   radioresistance.";
RL   Genomics Inform. 11:245-253(2013).
//