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Cellosaurus HMT-3909S13 (CVCL_UW65)

[Text version]
Cell line name HMT-3909S13
Synonyms HMT3909S13; HMT-3909/S13; HMT-3909 subline S13
Accession CVCL_UW65
Resource Identification Initiative To cite this cell line use: HMT-3909S13 (RRID:CVCL_UW65)
Comments Group: Triple negative breast cancer (TNBC) cell line.
Population: Caucasian.
Characteristics: Appears to be a progenitor cell line. Produces myoepithelial cells at the stromal-epithelial junction in tumors generated in nude mice.
Derived from site: In situ; Breast; UBERON=UBERON_0000310.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg249Gly (c.745A>G); ClinVar=VCV000376654; Zygosity=Unspecified (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_6857 (HMT-3909S8)
CVCL_UW66 (HMT-3909S13 clone A4)CVCL_UW67 (HMT-3909S13 clone G4)CVCL_UW68 (HMT-3909S16)
Sex of cell Female
Age at sampling 61Y
Category Cancer cell line

PubMed=11801722; DOI=10.1242/jcs.115.1.39
Gudjonsson T., Ronnov-Jessen L., Villadsen R., Rank F., Bissell M.J., Petersen O.W.
Normal and tumor-derived myoepithelial cells differ in their ability to interact with luminal breast epithelial cells for polarity and basement membrane deposition.
J. Cell Sci. 115:39-50(2002)

PubMed=16807805; DOI=10.1007/s10911-005-9586-4
Gudjonsson T., Adriance M.C., Sternlicht M.D., Petersen O.W., Bissell M.J.
Myoepithelial cells: their origin and function in breast morphogenesis and neoplasia.
J. Mammary Gland Biol. Neoplasia 10:261-272(2005)

PubMed=22692575; DOI=10.2119/molmed.2012.00091
Leth-Larsen R., Terp M.G., Christensen A.G., Elias D., Kuhlwein T., Jensen O.N., Petersen O.W., Ditzel H.J.
Functional heterogeneity within the CD44 high human breast cancer stem cell-like compartment reveals a gene signature predictive of distant metastasis.
Mol. Med. 18:1109-1121(2012)

Cell line databases/resources cancercelllines; CVCL_UW65
Encyclopedic resources Wikidata; Q94213575
Entry history
Entry creation25-Feb-2019
Last entry update05-Oct-2023
Version number6