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Cellosaurus imHC (CVCL_UR52)

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Cell line name imHC
Synonyms BMI/hTERT-MSC; immortalized Hepatocyte-like Cell line
Accession CVCL_UR52
Resource Identification Initiative To cite this cell line use: imHC (RRID:CVCL_UR52)
Comments Group: Malaria research cell line.
Characteristics: Supports Plasmodium vivax liver-stage development (PubMed=29370800).
Doubling time: 45 hours (PubMed=29370800).
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
Genetic integration: Method=Transduction; Gene=MGI; MGI:88174; Bmi1.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Cell type: Mesenchymal stem cell derived hepatocyte.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_XY59 (imHC-FVII)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Telomerase immortalized cell line
Publications

PubMed=21961524; DOI=10.1186/1472-6750-11-89; PMCID=PMC3198927
Khanit Sa-ngiamsuntorn, Adisak Wongkajornsilp, Kanda Kasetsinsombat, Sunisa Duangsa-ard, Lalana Nuntakarn, Suparerk Borwornpinyo, Pravit Akarasereenont, Somchai Limsrichamrern, Suradej Hongeng;
Upregulation of CYP 450s expression of immortalized hepatocyte-like cells derived from mesenchymal stem cells by enzyme inducers.
BMC Biotechnol. 11:89.1-89.15(2011)

PubMed=29370800; DOI=10.1186/s12936-018-2198-4; PMCID=PMC5785895
Yongyut Pewkliang, Siriwan Rungin, Kaewta Lerdpanyangam, Apisak Duangmanee, Phongthon Kanjanasirirat, Phichaya Suthivanich, Khanit Sa-ngiamsuntorn, Suparerk Borwornpinyo, Jetsumon Sattabongkot, Rapatbhorn Patrapuvich, Suradej Hongeng;
A novel immortalized hepatocyte-like cell line (imHC) supports in vitro liver stage development of the human malarial parasite Plasmodium vivax.
Malar. J. 17:50.1-50.14(2018)

PubMed=31381603; DOI=10.1371/journal.pone.0220825; PMCID=PMC6681952
Sarai Pongjantarasatian, Praguywan Kadegasem, Werasak Sasanakul, Khanit Sa-ngiamsuntorn, Suparerk Borwornpinyo, Nongnuch Sirachainan, Ampaiwan Chuansumrit, Pansakorn Tanratana, Suradej Hongeng;
Coagulant activity of recombinant human factor VII produced by lentiviral human F7 gene transfer in immortalized hepatocyte-like cell line.
PLoS ONE 14:e0220825.1-e0220825.12(2019)

Cross-references
Encyclopedic resources Wikidata; Q94316264
Entry history
Entry creation25-Feb-2019
Last entry update27-Nov-2025
Version number10