ID   imHC
AC   CVCL_UR52
SY   BMI/hTERT-MSC; immortalized Hepatocyte-like Cell line
DR   Wikidata; Q94316264
RX   PubMed=21961524;
RX   PubMed=29370800;
RX   PubMed=31381603;
CC   Group: Malaria research cell line.
CC   Characteristics: Supports Plasmodium vivax liver-stage development (PubMed=29370800).
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
CC   Genetic integration: Method=Transduction; Gene=MGI; MGI:88174; Bmi1.
CC   Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
CC   Cell type: Mesenchymal stem cell derived hepatocyte.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Sex unspecified
AG   Age unspecified
CA   Telomerase immortalized cell line
DT   Created: 25-02-19; Last updated: 19-12-24; Version: 9
//
RX   PubMed=21961524; DOI=10.1186/1472-6750-11-89; PMCID=PMC3198927;
RA   Sa-ngiamsuntorn K., Wongkajornsilp A., Kasetsinsombat K.,
RA   Duangsa-ard S., Nuntakarn L., Borwornpinyo S., Akarasereenont P.,
RA   Limsrichamrern S., Hongeng S.;
RT   "Upregulation of CYP 450s expression of immortalized hepatocyte-like
RT   cells derived from mesenchymal stem cells by enzyme inducers.";
RL   BMC Biotechnol. 11:89.1-89.15(2011).
//
RX   PubMed=29370800; DOI=10.1186/s12936-018-2198-4; PMCID=PMC5785895;
RA   Pewkliang Y., Rungin S., Lerdpanyangam K., Duangmanee A.,
RA   Kanjanasirirat P., Suthivanich P., Sa-ngiamsuntorn K.,
RA   Borwornpinyo S., Sattabongkot J., Patrapuvich R., Hongeng S.;
RT   "A novel immortalized hepatocyte-like cell line (imHC) supports in
RT   vitro liver stage development of the human malarial parasite
RT   Plasmodium vivax.";
RL   Malar. J. 17:50.1-50.14(2018).
//
RX   PubMed=31381603; DOI=10.1371/journal.pone.0220825; PMCID=PMC6681952;
RA   Pongjantarasatian S., Kadegasem P., Sasanakul W., Sa-ngiamsuntorn K.,
RA   Borwornpinyo S., Sirachainan N., Chuansumrit A., Tanratana P.,
RA   Hongeng S.;
RT   "Coagulant activity of recombinant human factor VII produced by
RT   lentiviral human F7 gene transfer in immortalized hepatocyte-like cell
RT   line.";
RL   PLoS ONE 14:e0220825.1-e0220825.12(2019).
//