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Cellosaurus A375-Luc2 (CVCL_UR32)

[Text version]
Cell line name A375-Luc2
Accession CVCL_UR32
Resource Identification Initiative To cite this cell line use: A375-Luc2 (RRID:CVCL_UR32)
Comments Population: Caucasian.
Characteristics: Stably expresses firefly luciferase under the control of the human EF1a promoter (ATCC=CRL-1619-LUC2).
Genetic integration: Method=Transduction; Gene=UniProtKB; P33967; Bacillus cereus Bsr.
Genetic integration: Method=Transduction; Gene=UniProtKB; P08659; Photinus pyralis firefly-type luciferase (Note=With optimized codon usage for mammalian expression = Luc2).
Derived from site: In situ; Leg, skin; UBERON=UBERON_0001511.
Sequence variations
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Glu61Ter (c.181G>T) (p.Gly75Val, c.224G>T); ClinVar=VCV000376309; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Glu69Ter (c.205G>T) (p.Gly83Val, c.248G>T); ClinVar=VCV000376308; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Amelanotic melanoma (NCIt: C3802)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0132 (A-375)
Sex of cell Female
Age at sampling 54Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-1619-LUC2

Markers:
AmelogeninX
CSF1PO11,12
D5S81812
D7S8209
D13S31711,14
D16S5399
TH018
TPOX8,10
vWA16,17

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Cross-references
Cell line collections (Providers) ATCC; CRL-1619-LUC2
Cell line databases/resources cancercelllines; CVCL_UR32
Encyclopedic resources Wikidata; Q93311724
Entry history
Entry creation25-Feb-2019
Last entry update14-Aug-2025
Version number15