Cellosaurus cell line 518A2 (CVCL

Cellosaurus 518A2 (CVCL_UM77)

Cross-references
Cell line name	518A2
Synonyms	518.A2
Accession	CVCL_UM77
Resource Identification Initiative	To cite this cell line use: 518A2 (RRID:CVCL_UM77)
Comments	Omics: Transcriptomics; RNAseq. Derived from site: Metastatic; Not specified.
Sequence variations	Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg213Gln (c.638G>A); ClinVar=VCV000135359; Zygosity=Unspecified (PubMed=10070891).
Disease	Melanoma (NCIt: C3224)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual	CVCL_UM89 ! 518A1 CVCL_UM90 ! 518B
Sex of cell	Sex unspecified
Age at sampling	Age unspecified
Category	Cancer cell line
Publications	PubMed=10070891; DOI=10.1038/sj.bjc.6690147; PMCID=PMC2362648 Shuraila Francisca Zerp, Andrea van Elsas, Lucy T.C. Peltenburg, Peter I. Schrier; p53 mutations in human cutaneous melanoma correlate with sun exposure but are not always involved in melanomagenesis. Br. J. Cancer 79:921-926(1999) PubMed=25502142; DOI=10.1038/ncomms6712; PMCID=PMC4428333 Judith Muller, Oscar Krijgsman, Jennifer Tsoi, Lidia Robert, Willy Hugo, Chunying Song, Xiang-Ju Kong, Patricia Abrao Possik, Paulien D.M. Cornelissen-Steijger, Marnix H. Geukes Foppen, Kristel Kemper ...Show all 19 authors... , Colin Ronald Goding, Ultan McDermott, Christian Blank, John Haanen, Thomas G. Graeber, Antoni Ribas, Roger S. Lo, Daniel S. Peeper; Show fewer authors Low MITF/AXL ratio predicts early resistance to multiple targeted drugs in melanoma. Nat. Commun. 5:5712.1-5712.15(2014)
Cell line databases/resources	cancercelllines; CVCL_UM77
Chemistry resources	ChEMBL-Cells; CHEMBL4483167 ChEMBL-Targets; CHEMBL4483222 PubChem_Cell_line; CVCL_UM77
Encyclopedic resources	Wikidata; Q93307666
Gene expression databases	GEO; GSM1507935
Polymorphism and mutation databases	Cosmic; 1418466 IARC_TP53; 10952
Entry history
Entry creation	25-Feb-2019
Last entry update	10-Apr-2025
Version number	10