ID   518A2
AC   CVCL_UM77
SY   518.A2
DR   cancercelllines; CVCL_UM77
DR   ChEMBL-Cells; CHEMBL4483167
DR   ChEMBL-Targets; CHEMBL4483222
DR   Cosmic; 1418466
DR   GEO; GSM1507935
DR   IARC_TP53; 10952
DR   PubChem_Cell_line; CVCL_UM77
DR   Wikidata; Q93307666
RX   PubMed=10070891;
RX   PubMed=25502142;
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg213Gln (c.638G>A); ClinVar=VCV000135359; Zygosity=Unspecified (PubMed=10070891).
CC   Omics: Transcriptomics; RNAseq.
CC   Derived from site: Metastatic; Not specified.
DI   NCIt; C3224; Melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_UM89 ! 518A1
OI   CVCL_UM90 ! 518B
SX   Sex unspecified
AG   Age unspecified
CA   Cancer cell line
DT   Created: 25-02-19; Last updated: 10-04-25; Version: 10
//
RX   PubMed=10070891; DOI=10.1038/sj.bjc.6690147; PMCID=PMC2362648;
RA   Zerp S.F., van Elsas A., Peltenburg L.T.C., Schrier P.I.;
RT   "p53 mutations in human cutaneous melanoma correlate with sun exposure
RT   but are not always involved in melanomagenesis.";
RL   Br. J. Cancer 79:921-926(1999).
//
RX   PubMed=25502142; DOI=10.1038/ncomms6712; PMCID=PMC4428333;
RA   Muller J., Krijgsman O., Tsoi J., Robert L., Hugo W., Song C.,
RA   Kong X.-J., Possik P.A., Cornelissen-Steijger P.D.M., Geukes Foppen M.H.,
RA   Kemper K., Goding C.R., McDermott U., Blank C., Haanen J.B.A.G.,
RA   Graeber T.G., Ribas A., Lo R.S., Peeper D.S.;
RT   "Low MITF/AXL ratio predicts early resistance to multiple targeted
RT   drugs in melanoma.";
RL   Nat. Commun. 5:5712.1-5712.15(2014).
//