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Cellosaurus DPX2 (CVCL_UK01)

[Text version]
Cell line name DPX2
Synonyms DPX-2
Accession CVCL_UK01
Resource Identification Initiative To cite this cell line use: DPX2 (RRID:CVCL_UK01)
Comments Population: Caucasian.
Biotechnology: Used in cell-based assays for a parallel assessment of CYP3A4 induction, metabolism and inhibition at the cellular level.
Characteristics: The luciferase reporter gene is under the control of CYP3A4 response elements (proximal promoter and distal xenobiotic-responsive enhancer module).
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:7968; NR1I2.
Genetic integration: Method=Transfection; Gene=UniProtKB; P08659; Photinus pyralis firefly-type luciferase.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Hepatoblastoma (NCIt: C3728)
Hepatoblastoma (ORDO: Orphanet_449)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0027 (Hep-G2)
Sex of cell Male
Age at sampling 15Y
Category Cancer cell line
Web pages Info; Promega; -; https://www.promegaconnections.com/tag/dpx2-cells/
Publications

PubMed=15466163; DOI=10.1124/dmd.104.001594
Mei-Fei Yueh, Marleen Kawahara, Judy L. Raucy;
High volume bioassays to assess CYP3A4-mediated drug interactions: induction and inhibition in a single cell line.
Drug Metab. Dispos. 33:38-48(2005)

PubMed=16146350; DOI=10.1208/aapsj070102; PMCID=PMC2751492
Olga V. Trubetskoy, Bryan Marks, Thomas Zielinski, Mei-Fei Yueh, Judy L. Raucy;
A simultaneous assessment of CYP3A4 metabolism and induction in the DPX-2 cell line.
AAPS J. 7:E6-E13(2005)

PubMed=22912432; DOI=10.1124/dmd.112.047456
Odette A. Fahmi, Judy L. Raucy, Elsa Ponce, Saleema Hassanali, Jerome M. Lasker;
Utility of DPX2 cells for predicting CYP3A induction-mediated drug-drug interactions and associated structure-activity relationships.
Drug Metab. Dispos. 40:2204-2211(2012)

Cross-references
Cell line databases/resources CLO; CLO_0037254
cancercelllines; CVCL_UK01
Chemistry resources PubChem_Cell_line; CVCL_UK01
Encyclopedic resources Wikidata; Q93531270
Entry history
Entry creation25-Feb-2019
Last entry update14-Aug-2025
Version number15