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Cellosaurus R/VP-16 (CVCL_UJ12)

[Text version]
Cell line name R/VP-16
Accession CVCL_UJ12
Resource Identification Initiative To cite this cell line use: R/VP-16 (RRID:CVCL_UJ12)
Comments Population: African; Nigerian.
Selected for resistance to: ChEBI; CHEBI:4911; Etoposide (VP-16).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Derived from site: In situ; Bone, jaw, maxilla; UBERON=UBERON_0002397.
Cell type: B-cell; CL=CL_0000236.
Sequence variations
  • Gene fusion; HGNC; 5477; IGH + HGNC; 7553; MYC; Name(s)=MYC-IGH (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg213Gln (c.638G>A); ClinVar=VCV000135359; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Tyr234His (c.700T>C); ClinVar=VCV000376691; Zygosity=Heterozygous (from parent cell line).
Disease EBV-related Burkitt lymphoma (NCIt: C27694)
Burkitt lymphoma (ORDO: Orphanet_543)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0511 (Raji)
Sex of cell Male
Age at sampling 11Y
Category Cancer cell line

Treichel R.S.
Susceptibility to LAK-mediated cytotoxicity of multidrug-resistant variants of the human RAJI cell line is not related to expression of major cellular adhesion molecules.
Ohio J. Sci. 93:14-18(1993)

PubMed=8099376; DOI=10.1016/0145-2126(93)90124-4
Treichel R.S.
Autologous bone marrow transplantation for leukemia: monoclonal antibody-mediated purging of multidrug-resistant leukemia.
Leuk. Res. 17:491-499(1993)

Cell line databases/resources cancercelllines; CVCL_UJ12
Encyclopedic resources Wikidata; Q98128775
Entry history
Entry creation25-Feb-2019
Last entry update02-May-2024
Version number12