Cellosaurus cell line UCSD237i-APP1-2 APPnull (CVCL

Cross-references
Cell line name	UCSD237i-APP1-2 APPnull
Synonyms	APPDp1.2 APPnull; APP 1KO; APPnull in APPdp1.2 background
Accession	CVCL_UI23
Resource Identification Initiative	To cite this cell line use: UCSD237i-APP1-2 APPnull (RRID:CVCL_UI23)
Comments	Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:620; APP. Derived from site: In situ; Skin; UBERON=UBERON_0002097. Cell type: Fibroblast of skin; CL=CL_0002620.
Disease	Alzheimer's disease 1 (NCIt: C146894) Early-onset autosomal dominant Alzheimer disease (ORDO: Orphanet_1020)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_EJ97 (UCSD237i-APP1-2)
Sex of cell	Male
Age at sampling	51Y
Category	Induced pluripotent stem cell
Publications	PubMed=30686764; DOI=10.1016/j.stem.2018.12.013; PMCID=PMC6414424 Rik van der Kant, Vanessa F. Langness, Cheryl M. Herrera, Daniel A. Williams, Lauren K. Fong, Yves Leestemaker, Evelyne Steenvoorden, Kevin D. Rynearson, Jos F. Brouwers, J. Bernd Helms, Huib Ovaa ...Show all 15 authors... , Martin Giera, Steven L. Wagner, Anne G. Bang, Lawrence Steven B. Goldstein; Show fewer authors Cholesterol metabolism is a druggable axis that independently regulates Tau and amyloid-beta in iPSC-derived Alzheimer's disease neurons. Cell Stem Cell 24:363-375.e9(2019)
Encyclopedic resources	Wikidata; Q98133861
Entry history
Entry creation	25-Feb-2019
Last entry update	10-Apr-2025
Version number	8