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Cellosaurus UCSD237i-APP1-2 (CVCL_EJ97)

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Cell line name UCSD237i-APP1-2
Synonyms APPDp1.2; Appdp1.2; APPdp1.2
Accession CVCL_EJ97
Resource Identification Initiative To cite this cell line use: UCSD237i-APP1-2 (RRID:CVCL_EJ97)
Comments Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Cell type: Fibroblast of skin; CL=CL_0002620.
Disease Alzheimer's disease 1 (NCIt: C146894)
Early-onset autosomal dominant Alzheimer disease (ORDO: Orphanet_1020)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_UI23 (UCSD237i-APP1-2 APPnull)
Originate from same individual CVCL_EJ96 ! UCSD236i-APP1-1
CVCL_EJ98 ! UCSD238i-APP1-3
Sex of cell Male
Age at sampling 51Y
Category Induced pluripotent stem cell
Publications

PubMed=22278060; DOI=10.1038/nature10821; PMCID=PMC3338985
Mason A. Israel, Shauna H. Yuan, Cedric Bardy, Sol M. Reyna, Yang-Ling Mu, Cheryl M. Herrera, Michael P. Hefferan, Sebastiaan F.J. Van Gorp, Kristopher L. Nazor, Francesca Sesillo Boscolo, Christian T. Carson ...Show all 17 authors... , Louise C. Laurent, Martin Marsala, Fred Harrison Gage, Anne Marja Portaankorva, Edward H. Koo, Lawrence Steven B. Goldstein; Show fewer authors
Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells.
Nature 482:216-220(2012)

PubMed=30686764; DOI=10.1016/j.stem.2018.12.013; PMCID=PMC6414424
Rik van der Kant, Vanessa F. Langness, Cheryl M. Herrera, Daniel A. Williams, Lauren K. Fong, Yves Leestemaker, Evelyne Steenvoorden, Kevin D. Rynearson, Jos F. Brouwers, J. Bernd Helms, Huib Ovaa ...Show all 15 authors... , Martin Giera, Steven L. Wagner, Anne G. Bang, Lawrence Steven B. Goldstein; Show fewer authors
Cholesterol metabolism is a druggable axis that independently regulates Tau and amyloid-beta in iPSC-derived Alzheimer's disease neurons.
Cell Stem Cell 24:363-375.e9(2019)

Cross-references
Cell line collections (Providers) WiCell; ucsd237i-app1-2 - Discontinued
Cell line databases/resources SKIP; SKIP005444
Encyclopedic resources Wikidata; Q54990043
Entry history
Entry creation26-Sep-2016
Last entry update10-Apr-2025
Version number14