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Cellosaurus TRF1 F/F (CVCL_UE12)

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Cell line name TRF1 F/F
Accession CVCL_UE12
Resource Identification Initiative To cite this cell line use: TRF1 F/F (RRID:CVCL_UE12)
Comments Characteristics: Embryonic fibroblasts that have loxP sites on both sides of the 1st coding exon of mouse Terf1 gene. Terf1 knockout can be effected by transduction of Cre recombinase into the cell line (ATCC=CRL-3316).
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03070; Simian virus 40 (SV40) large T antigen.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Derived from site: In situ; Embryo; UBERON=UBERON_0000922.
Cell type: Fibroblast; CL=CL_0000057.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: 129P2/Ola x C57BL/6J.
Sex of cell Sex unspecified
Age at sampling 13-14FD
Category Transformed cell line
Publications

PubMed=19596237; DOI=10.1016/j.cell.2009.06.021; PMCID=PMC2723738
Agnel Sfeir, Settapong T. Kosiyatrakul, Dirk Hockemeyer, Sheila L. MacRae, Jan Karlseder, Carl L. Schildkraut, Titia de Lange;
Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication.
Cell 138:90-103(2009)

Cross-references
Cell line collections (Providers) ATCC; CRL-3316
Encyclopedic resources Wikidata; Q98133536
Entry history
Entry creation13-Nov-2018
Last entry update14-Aug-2025
Version number7