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Cellosaurus MeWo-LC1 (CVCL_U937)

[Text version]
Cell line name MeWo-LC1
Accession CVCL_U937
Resource Identification Initiative To cite this cell line use: MeWo-LC1 (RRID:CVCL_U937)
Comments Group: Serum/protein free medium cell line.
Population: Caucasian.
Doubling time: 42 +- 2 hours (PubMed=3000950).
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000027.
Sequence variations
  • Gene deletion; HGNC; 1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 1787; CDKN2A; Simple; p.Arg80Ter (c.237_238CC>TT) (c.237_238delinsTT) (p.Pro94Leu, c.280_281CC>TT); Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 6877; MAPK3; Simple; p.Pro246Ser (c.736C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Gln317Ter (c.949C>T); ClinVar=VCV000450344; Zygosity=Unspecified (from parent cell line).
Disease Cutaneous melanoma (NCIt: C3510)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0445 (MeWo)
Sex of cell Male
Age at sampling 78Y
Category Cancer cell line

PubMed=3000950; DOI=10.1002/ijc.2910370120
Sauvaigo S., Fretts R.E., Riopelle R.J., Lagarde A.E.
Autonomous proliferation of MeWo human melanoma cell lines in serum-free medium: secretion of growth-stimulating activities.
Int. J. Cancer 37:123-132(1986)

Cell line databases/resources cancercelllines; CVCL_U937
Encyclopedic resources Wikidata; Q54905347
Entry history
Entry creation16-Apr-2014
Last entry update30-Jan-2024
Version number15