Cellosaurus cell line TTE3 (CVCL

Cellosaurus TTE3 (CVCL_U448)

Cross-references
Cell line name	TTE3
Synonyms	TTE 3
Accession	CVCL_U448
Secondary accession	CVCL_9808
Resource Identification Initiative	To cite this cell line use: TTE3 (RRID:CVCL_U448)
Comments	Characteristics: Proliferates at the permissive temperature (33 Celsius). Growth is signicantly prevented at the nonpermissive temperature (39 Celsius) (PubMed=11832784). Genetic integration: Method=Transgenic mouse; Gene=UniProtKB; P03070; Simian virus 40 (SV40) large T antigen. Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=tsA58). Omics: Transcriptomics; Microarray. Misspelling: TT3E; EFO=EFO_0002868. Derived from site: In situ; Testis; UBERON=UBERON_0000473. Cell type: Sertoli cell; CL=CL_0000216.
Species of origin	Mus musculus (Mouse) (NCBI Taxonomy: 10090) Breed/subspecies: C57BL/6 SV40-tsA58 transgenic.
Sex of cell	Male
Age at sampling	2M
Category	Conditionally immortalized cell line
Publications	PubMed=11832784; DOI=10.1016/S0022-5347(05)65359-1 Yoshiaki Tabuchi, Shoichiro Ohta, Nobuaki Yanai, Masuo Obinata, Takashi Kondo, Hideki Fuse, Shinji Asano; Development of the conditionally immortalized testicular Sertoli cell line TTE3 expressing Sertoli cell specific genes from mice transgenic for temperature sensitive simian virus 40 large T antigen gene. J. Urol. 167:1538-1545(2002) PubMed=15541572; DOI=10.1016/j.mce.2003.05.001 Nafis A. Rahman, Ilpo Tapani Huhtaniemi; Testicular cell lines. Mol. Cell. Endocrinol. 228:53-65(2004) PubMed=17233813; DOI=10.1111/j.1349-7006.2007.00399.x; PMCID=PMC11159456 Masuo Obinata; The immortalized cell lines with differentiation potentials: their establishment and possible application. Cancer Sci. 98:275-283(2007) PubMed=17543550; DOI=10.1016/j.cellbi.2007.04.007 Yoshiaki Tabuchi, Ichiro Takasaki, Atsumi Suto, Takashi Kondo, Yoshihisa Suzuki, Masuo Obinata; Genetic networks in nonpermissive temperature-induced cell differentiation of Sertoli TTE3 cells harboring temperature-sensitive SV40 large T-antigen. Cell Biol. Int. 31:1231-1236(2007)
Encyclopedic resources	Wikidata; Q54973226
Experimental variables resources	EFO; EFO_0002868
Entry history
Entry creation	03-Feb-2014
Last entry update	14-Aug-2025
Version number	17