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Cellosaurus HT4 [Mouse neurons] (CVCL_U378)

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Cell line name HT4 [Mouse neurons]
Synonyms HT-4
Accession CVCL_U378
Resource Identification Initiative To cite this cell line use: HT4 [Mouse neurons] (RRID:CVCL_U378)
Comments Characteristics: At the restrictive temperature (39 Celsius) the cells take on properties of differentiated neurons they express neuronal antigens, synthesize NGF mRNA and secrete biologically active NGF in vitro.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03070; Simian virus 40 (SV40) large T antigen.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=tsA58).
Derived from site: In situ; Brain, hippocampus; UBERON=UBERON_0002421.
Cell type: Neuron; CL=CL_0000540.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Hierarchy Children:
CVCL_0321 (HT22)
Category Transformed cell line
Publications

PubMed=1970639; DOI=10.1073/pnas.87.9.3518; PMCID=PMC53932
Bruce H. Morimoto, Daniel Edward Koshland Jr.;
Excitatory amino acid uptake and N-methyl-D-aspartate-mediated secretion in a neural cell line.
Proc. Natl. Acad. Sci. U.S.A. 87:3518-3521(1990)

PubMed=1980069; DOI=10.1016/0896-6273(90)90347-I
Bruce H. Morimoto, Daniel Edward Koshland Jr.;
Induction and expression of long- and short-term neurosecretory potentiation in a neural cell line.
Neuron 5:875-880(1990)

PubMed=2033646; DOI=10.1002/jnr.490280203
Scott R. Whittemore, Vicky R. Holets Whittemore, Robert W. Keane, Dan J. Levy, Ronald Davies Graham McKay;
Transplantation of a temperature-sensitive, nerve growth factor-secreting, neuroblastoma cell line into adult rats with fimbria-fornix lesions rescues cholinergic septal neurons.
J. Neurosci. Res. 28:156-170(1991)

Cross-references
Encyclopedic resources Wikidata; Q54896597
Entry history
Entry creation03-Feb-2014
Last entry update27-Nov-2025
Version number17