Cellosaurus logo
expasy logo

Cellosaurus PC-9/f14 (CVCL_U149)

[Text version]
Cell line name PC-9/f14
Synonyms PC9/f14
Accession CVCL_U149
Resource Identification Initiative To cite this cell line use: PC-9/f14 (RRID:CVCL_U149)
Comments Population: Chinese; Han and Japanese.
Characteristics: Highly metastatic. Established after five additional passages of the parent cell line in nude mice (PubMed=11506965).
Omics: Transcriptomics; Microarray.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Glu746_Ala750del (c.2235_2249del15); ClinVar=VCV000163343; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_U150 (PC-9/f9)
Sex of cell Male
Age at sampling 45Y
Category Cancer cell line
Publications

PubMed=11506965; DOI=10.1016/S0959-8049(01)00154-X
Akihiko Gemma, Kiyoshi Takenaka, Yoko Hosoya, Kuniko Matuda, Masahiro Seike, Fumiko Kurimoto, Yasushi Ono, Kazutsugu Uematsu, Yuichiro Takeda, Suguru Hibino, A. Yoshimura ...Show all 13 authors... , Masahiko Shibuya, Shoji Kudoh; Show fewer authors
Altered expression of several genes in highly metastatic subpopulations of a human pulmonary adenocarcinoma cell line.
Eur. J. Cancer 37:1554-1561(2001)

PubMed=12696064; DOI=10.1002/gcc.10205
Akinobu Yoshimura, Akihiko Gemma, Yoko Hosoya, Eriko Komaki, Yukio Hosomi, Tetsuya Okano, Kiyoshi Takenaka, Kuniko Matuda, Masahiro Seike, Kazutsugu Uematsu, Suguru Hibino ...Show all 15 authors... , Masahiko Shibuya, Tesshi Yamada, Setsuo Hirohashi, Shoji Kudoh; Show fewer authors
Increased expression of the LGALS3 (galectin 3) gene in human non-small-cell lung cancer.
Genes Chromosomes Cancer 37:159-164(2003)

PubMed=17982658; DOI=10.3892/ijo.31.6.1325
Akira Takemura, Akihiko Gemma, Masahiko Shibuya, Kuniko Matsuda, Tetsuya Okano, Michiya Nara, Rintarou Noro, Yuji Minegishi, Akinobu Yoshimura, Shoji Kudoh;
Gemcitabine resistance in a highly metastatic subpopulation of a pulmonary adenocarcinoma cell line resistant to gefitinib.
Int. J. Oncol. 31:1325-1332(2007)

Cross-references
Cell line databases/resources cancercelllines; CVCL_U149
Encyclopedic resources Wikidata; Q54938492
Polymorphism and mutation databases Cosmic; 915331
Entry history
Entry creation03-Feb-2014
Last entry update10-Apr-2025
Version number19