ID   PC-9/f14
AC   CVCL_U149
SY   PC9/f14
DR   cancercelllines; CVCL_U149
DR   Cosmic; 915331
DR   Wikidata; Q54938492
RX   PubMed=11506965;
RX   PubMed=12696064;
RX   PubMed=17982658;
CC   Population: Chinese; Han and Japanese.
CC   Characteristics: Highly metastatic. Established after five additional passages of the parent cell line in nude mice (PubMed=11506965).
CC   Sequence variation: Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Glu746_Ala750del (c.2235_2249del15); ClinVar=VCV000163343; Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
CC   Omics: Transcriptomics; Microarray.
CC   Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
DI   NCIt; C3512; Lung adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_U150 ! PC-9/f9
SX   Male
AG   45Y
CA   Cancer cell line
DT   Created: 03-02-14; Last updated: 10-04-25; Version: 19
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RX   PubMed=11506965; DOI=10.1016/S0959-8049(01)00154-X;
RA   Gemma A., Takenaka K., Hosoya Y., Matuda K., Seike M., Kurimoto F.,
RA   Ono Y., Uematsu K., Takeda Y., Hibino S., Yoshimura A., Shibuya M.,
RA   Kudoh S.;
RT   "Altered expression of several genes in highly metastatic
RT   subpopulations of a human pulmonary adenocarcinoma cell line.";
RL   Eur. J. Cancer 37:1554-1561(2001).
//
RX   PubMed=12696064; DOI=10.1002/gcc.10205;
RA   Yoshimura A., Gemma A., Hosoya Y., Komaki E., Hosomi Y., Okano T.,
RA   Takenaka K., Matuda K., Seike M., Uematsu K., Hibino S., Shibuya M.,
RA   Yamada T., Hirohashi S., Kudoh S.;
RT   "Increased expression of the LGALS3 (galectin 3) gene in human
RT   non-small-cell lung cancer.";
RL   Genes Chromosomes Cancer 37:159-164(2003).
//
RX   PubMed=17982658; DOI=10.3892/ijo.31.6.1325;
RA   Takemura A., Gemma A., Shibuya M., Matsuda K., Okano T., Nara M.,
RA   Noro R., Minegishi Y., Yoshimura A., Kudoh S.;
RT   "Gemcitabine resistance in a highly metastatic subpopulation of a
RT   pulmonary adenocarcinoma cell line resistant to gefitinib.";
RL   Int. J. Oncol. 31:1325-1332(2007).
//