• Gene fusion; HGNC; HGNC:9113; PML + HGNC; HGNC:9864; RARA; Name(s)=PML-RARA (from parent cell line).
  
• Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Ala18Asp (c.53C>A); Zygosity=Heterozygous (from parent cell line).
  
• Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
  

PubMed=8395911; DOI=10.1182/blood.V82.5.1573.1573
Said Dermime, Francesco Grignani, Monica Clerici, Clara Nervi, Gabriella Sozzi, Gian Paolo Talamo, Edoardo Marchesi, Franca Formelli, Giorgio Parmiani, Pier Giuseppe Pelicci, Carlo Gambacorti-Passerini;
Occurrence of resistance to retinoic acid in the acute promyelocytic leukemia cell line NB4 is associated with altered expression of the pml/RAR alpha protein.
Blood 82:1573-1577(1993)

PubMed=7719237; DOI=10.3109/10428199509049768
Said Dermime, Francesco Grignani, Daniela Rogaia, Concetta Liberatore, Edoardo Marchesi, Carlo Gambacorti-Passerini;
Acute promyelocytic leukaemia cells resistant to retinoic acid show further perturbation of the RAR alpha signal transduction system.
Leuk. Lymphoma 16:289-295(1995)

PubMed=11704857; DOI=10.1038/sj.onc.1204863
Mathilde J.S. Roussel, Michel Lanotte;
Maturation sensitive and resistant t(15;17) NB4 cell lines as tools for APL physiopathology: nomenclature of cells and repertory of their known genetic alterations and phenotypes.
Oncogene 20:7287-7291(2001)

PubMed=36982453; DOI=10.3390/ijms24065377; PMCID=PMC10049680
Rafal Skopek, Malgorzata Palusinska, Katarzyna Kaczor-Keller, Rafal Pingwara, Anna Papierniak-Wygladala, Tino Schenk, Slawomir Lewicki, Artur Zelent, Lukasz Szymanski;
Choosing the right cell line for acute myeloid leukemia (AML) research.
Int. J. Mol. Sci. 24:5377.1-5377.34(2023)