ID   NB4.306
AC   CVCL_U084
SY   NB4-306; NB4-GR306
DR   cancercelllines; CVCL_U084
DR   Wikidata; Q54907537
RX   PubMed=8395911;
RX   PubMed=11704857;
CC   Population: Caucasian.
CC   Sequence variation: Gene fusion; HGNC; HGNC:9113; PML + HGNC; HGNC:9864; RARA; Name(s)=PML-RARA (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Ala18Asp (c.53C>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
DI   NCIt; C3182; Acute promyelocytic leukemia with PML-RARA
DI   ORDO; Orphanet_520; Acute promyelocytic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0005 ! NB4
SX   Female
AG   23Y
CA   Cancer cell line
DT   Created: 03-02-14; Last updated: 19-12-24; Version: 18
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RX   PubMed=8395911; DOI=10.1182/blood.V82.5.1573.1573;
RA   Dermime S., Grignani F., Clerici M., Nervi C., Sozzi G., Talamo G.P.,
RA   Marchesi E., Formelli F., Parmiani G., Pelicci P.G.,
RA   Gambacorti-Passerini C.;
RT   "Occurrence of resistance to retinoic acid in the acute promyelocytic
RT   leukemia cell line NB4 is associated with altered expression of the
RT   pml/RAR alpha protein.";
RL   Blood 82:1573-1577(1993).
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RX   PubMed=11704857; DOI=10.1038/sj.onc.1204863;
RA   Roussel M.J.S., Lanotte M.;
RT   "Maturation sensitive and resistant t(15;17) NB4 cell lines as tools
RT   for APL physiopathology: nomenclature of cells and repertory of their
RT   known genetic alterations and phenotypes.";
RL   Oncogene 20:7287-7291(2001).
//