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Cellosaurus D1 [Mouse thymocyte] (CVCL_S911)

[Text version]
Cell line name D1 [Mouse thymocyte]
Accession CVCL_S911
Resource Identification Initiative To cite this cell line use: D1 [Mouse thymocyte] (RRID:CVCL_S911)
Comments Characteristics: IL7 dependent. Withdrawal of IL7 induces arrest in G1 phase of the cell cycle, followed by apoptosis (PubMed=12609543).
Characteristics: Does not express CD4 and CD8 (PubMed=12609543).
Knockout cell: Method=KO mouse; MGI; MGI:98834; Trp53.
Derived from site: In situ; Thymus; UBERON=UBERON_0002370.
Cell type: Thymocyte; CL=CL_0000893.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Hierarchy Children:
CVCL_7184 (D1F4)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Factor-dependent cell line
Web pages Info; COPE; -; http://www.cells-talk.com/index.php/page/copelibrary?key=D1
Publications

PubMed=10588730; DOI=10.1073/pnas.96.25.14476; PMCID=PMC24461
Khaled A.R., Kim K., Hofmeister R., Muegge K., Durum S.K.
Withdrawal of IL-7 induces Bax translocation from cytosol to mitochondria through a rise in intracellular pH.
Proc. Natl. Acad. Sci. U.S.A. 96:14476-14481(1999)

PubMed=12609543; DOI=10.1016/S0022-1759(02)00513-6
Kim K., Khaled A.R., Reynolds D., Young H.A., Lee C.-K., Durum S.K.
Characterization of an interleukin-7-dependent thymic cell line derived from a p53(-/-) mouse.
J. Immunol. Methods 274:177-184(2003)

Cross-references
Encyclopedic resources Wikidata; Q54817154
Entry history
Entry creation03-Feb-2014
Last entry update10-Apr-2025
Version number11