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Cellosaurus NKNT-3 (CVCL_S905)

[Text version]
Cell line name NKNT-3
Accession CVCL_S905
Resource Identification Initiative To cite this cell line use: NKNT-3 (RRID:CVCL_S905)
Comments Group: Serum/protein free medium cell line.
Characteristics: The SV40 T antigen is flanked by LoxP recombination targets so that it can be excised by Cre/Lox site-specific recombination.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; Q9QNF7; Human herpesvirus 1 TK.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Cell type: Hepatocyte; CL=CL_0000182.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Sex unspecified
Age at sampling Adult
Category Transformed cell line
Publications

PubMed=10678831; DOI=10.1126/science.287.5456.1258
Naoya Kobayashi, Toshiyoshi Fujiwara, Karen A. Westerman, Yusuke Inoue, Masakiyo Sakaguchi, Hirofumi Noguchi, Masahiro Miyazaki, Jin Cai, Noriaki Tanaka, Ira J. Fox, Philippe Leboulch;
Prevention of acute liver failure in rats with reversibly immortalized human hepatocytes.
Science 287:1258-1262(2000)

PubMed=10937342
Naoya Kobayashi, Hirofumi Noguchi, Takamasa Watanabe, Toshihisa Matsumura, Toshinori Totsugawa, Toshiyoshi Fujiwara, Karen A. Westerman, Philippe Leboulch, Ira J. Fox, Noriaki Tanaka;
Establishment of a tightly regulated human cell line for the development of hepatocyte transplantation.
Hum. Cell 13:7-13(2000)

PubMed=16970284; DOI=10.3727/000000006783981873
Ruurdtje Hoekstra, Tanja Deurholt, Lysbeth ten Bloemendaal, Mireille Desille, Albert C.W.A. van Wijk, Bruno Clement, Ronald P.J. Oude Elferink, Thomas M. van Gulik, Robert A.F.M. Chamuleau;
Assessment of in vitro applicability of reversibly immortalized NKNT-3 cells and clonal derivatives.
Cell Transplant. 15:423-433(2006)

Cross-references
Encyclopedic resources Wikidata; Q54930683
Entry history
Entry creation03-Feb-2014
Last entry update10-Sep-2024
Version number14