Cellosaurus cell line NKNT-3 (CVCL

Cellosaurus NKNT-3 (CVCL_S905)

Cross-references
Cell line name	NKNT-3
Accession	CVCL_S905
Resource Identification Initiative	To cite this cell line use: NKNT-3 (RRID:CVCL_S905)
Comments	Group: Serum/protein free medium cell line. Characteristics: The SV40 T antigen is flanked by LoxP recombination targets so that it can be excised by Cre/Lox site-specific recombination. Transfected with: UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR). Transfected with: UniProtKB; Q9QNF7; Human herpesvirus 1 TK. Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40). Derived from site: In situ; Liver; UBERON=UBERON_0002107. Cell type: Hepatocyte; CL=CL_0000182.
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell	Sex unspecified
Age at sampling	Adult
Category	Transformed cell line
Publications	PubMed=10678831; DOI=10.1126/science.287.5456.1258 Kobayashi N., Fujiwara T., Westerman K.A., Inoue Y., Sakaguchi M., Noguchi H., Miyazaki M., Cai J., Tanaka N., Fox I.J., Leboulch P. Prevention of acute liver failure in rats with reversibly immortalized human hepatocytes. Science 287:1258-1262(2000) PubMed=10937342 Kobayashi N., Noguchi H., Watanabe T., Matsumura T., Totsugawa T., Fujiwara T., Westerman K.A., Leboulch P., Fox I.J., Tanaka N. Establishment of a tightly regulated human cell line for the development of hepatocyte transplantation. Hum. Cell 13:7-13(2000) PubMed=16970284; DOI=10.3727/000000006783981873 Hoekstra R., Deurholt T., ten Bloemendaal L., Desille M., van Wijk A.C.W.A., Clement B., Oude Elferink R.P.J., van Gulik T.M., Chamuleau R.A.F.M. Assessment of in vitro applicability of reversibly immortalized NKNT-3 cells and clonal derivatives. Cell Transplant. 15:423-433(2006)
Encyclopedic resources	Wikidata; Q54930683
Entry history
Entry creation	03-Feb-2014
Last entry update	05-Oct-2023
Version number	13