Cellosaurus logo
expasy logo

Cellosaurus T37i (CVCL_S893)

[Text][XML][JSON]
Cell line name T37i
Accession CVCL_S893
Resource Identification Initiative To cite this cell line use: T37i (RRID:CVCL_S893)
Comments Characteristics: Can differentiate into brown adipocytes when incubated with triiodothyronine (T3) and insulin over 3-6 days. Differentiation can also be induced by incubation with steroid hormones such as aldosterone, which induces differentiation through its interaction with mineralocorticoid receptor (MR) (Millipore=SCC250).
Genetic integration: Method=Transgenic mouse; Gene=UniProtKB; P03070; Simian virus 40 (SV40) large T antigen.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Derived from site: In situ; Brown adipose tissue; UBERON=UBERON_0001348.
Disease Mouse hibernoma (NCIt: C21634)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C57BL/6 x DBA/2 SV40TAg transgenic.
Sex of cell Female
Age at sampling 2W
Category Transformed cell line
STR profile Source(s): Millipore=SCC250

Markers:
Mouse STR 1-117
Mouse STR 1-218
Mouse STR 2-116
Mouse STR 3-214.2
Mouse STR 4-219.3,20.3
Mouse STR 5-513
Mouse STR 6-418
Mouse STR 6-712,16
Mouse STR 7-126.2
Mouse STR 8-116,17
Mouse STR 11-216,17
Mouse STR 12-116
Mouse STR 13-117
Mouse STR 15-322.3
Mouse STR 17-215
Mouse STR 18-316
Mouse STR 19-212,13
Mouse STR X-126

Run an STR similarity search on this cell line
Publications

PubMed=9502766; DOI=10.1172/JCI1915; PMCID=PMC508679
Maria-Christina Zennaro, Damien Le Menuet, Say Viengchareun, Francine Walker, Daniel Ricquier, Marc Lombes;
Hibernoma development in transgenic mice identifies brown adipose tissue as a novel target of aldosterone action.
J. Clin. Invest. 101:1254-1260(1998)

PubMed=12482590; DOI=10.1016/S0014-5793(02)03697-9
Say Viengchareun, Maria-Christina Zennaro, Laurent Pascual-Le Tallec, Marc Lombes;
Brown adipocytes are novel sites of expression and regulation of adiponectin and resistin.
FEBS Lett. 532:345-350(2002)

Cross-references
Cell line collections (Providers) Millipore; SCC250
Encyclopedic resources Wikidata; Q54971528
Experimental variables resources EFO; EFO_0022805
Entry history
Entry creation03-Feb-2014
Last entry update14-Aug-2025
Version number14